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Application Data
(Analysis of Protein Array containing more than 19, 000 full-length human proteins using StAR Mouse Monoclonal Antibody (STAR/2154). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.)
Mouse StAR (Steroidogenic Acute Regulator) Monoclonal Antibody | anti-STAR antibody
StAR (Steroidogenic Acute Regulator) (Leydig Cell Marker)
Gene Names
STAR; STARD1
Reactivity
Human. Others not known.
Applications
Immunohistochemistry
Synonyms
StAR (Steroidogenic Acute Regulator), Antibody; StAR (Steroidogenic Acute Regulator) (Leydig Cell Marker); Cholesterol trafficker; Luteinizing hormone induced protein; Mitochondrial steroid acute regulatory protein; StAR; StAR related lipid transfer (START) domain containing 1; StARD1; START domain-containing protein 1; Steroid acute regulatory protein; Steroidogenic acute regulator (STAR); Steroidogenic acute regulatory protein mitochondrial; anti-STAR antibody
Host
Mouse
Reactivity
Human. Others not known.
Clonality
Monoclonal
Isotype
IgG1, kappa
Clone Number
STAR/2154
Specificity
Steroidogenic Acute Regulatory Protein (STAR) controls the rate-limiting step of steroidegenesis by translocating cholesterol from the outer mitochondrial membrane to the inner membrane where it is later cleaved to pregnenolone. It is primarily present in steroid-producing cells, including Leydig cells in the testis, theca cells and luteal cells in the ovary and adrenal cells in the adrenal cortex. Due to low levels of pregnenolone, seminomas and Leydig cell tumors display no specific STAR staining. Therefore, STAR antibody may assist in differentiating sex cord stromal tumors (SCST), seminomas and embryonal carcinomas.
Form/Format
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Sequence Length
285
Applicable Applications for anti-STAR antibody
IHC (Immunohistochemistry)
Immunogen
Recombinant fragment (around aa 39-108) of human STAR protein
Cellular Localization
Cytoplasmic (Mitochondria)
Hu-chromosome Location
8p11.23
Positive Control
K-562 cells. Adrenal or Testicular Carcinoma
Application Data
(Analysis of Protein Array containing more than 19, 000 full-length human proteins using StAR Mouse Monoclonal Antibody (STAR/2154). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.)
Application Data
(Analysis of Protein Array containing more than 19, 000 full-length human proteins using StAR Mouse Monoclonal Antibody (STAR/2154). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.)
SDS_PAGE
(SDS-PAGE Analysis Purified StAR Mouse Monoclonal Antibody (STAR/2154).Confirmation of Integrity and Purity of Antibody.)
SDS_PAGE
(SDS-PAGE Analysis Purified StAR Mouse Monoclonal Antibody (STAR/2154).Confirmation of Integrity and Purity of Antibody.)
IHC (Immunohistochemisry)
(Formalin-fixed, paraffin-embedded human Testicular Carcinoma stained with StAR Mouse Monoclonal Antibody (STAR/2154).)
IHC (Immunohistochemisry)
(Formalin-fixed, paraffin-embedded human Testicular Carcinoma stained with StAR Mouse Monoclonal Antibody (STAR/2154).)
IHC (Immunohiostchemistry)
(Formalin-fixed, paraffin-embedded human Testicular Carcinoma stained with StAR Mouse Monoclonal Antibody (STAR/2154).)
IHC (Immunohiostchemistry)
(Formalin-fixed, paraffin-embedded human Testicular Carcinoma stained with StAR Mouse Monoclonal Antibody (STAR/2154).)
IHC (Immunohistochemistry)
(Formalin-fixed, paraffin-embedded human Adrenal Gland stained with StAR Mouse Monoclonal Antibody (STAR/2154).)
IHC (Immunohistochemistry)
(Formalin-fixed, paraffin-embedded human Adrenal Gland stained with StAR Mouse Monoclonal Antibody (STAR/2154).)
References
Lin, D., Sugawara, T., Strauss, J.F., 3rd, Clark, B.J., Stocco, D.M., Saenger, P., Rogol, A. and Miller, W.L. 1995. Role of steroidogenic acute regulatory protein in adrenal and gonadal steroidogenesis. Science 267: 1828-1831. Pollack SE, et al. J Clin Endocrinol Metab. 1997; 82:4343-51.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
30kDa
NCBI Official Full Name
steroidogenic acute regulatory protein, mitochondrial
NCBI Official Synonym Full Names
steroidogenic acute regulatory protein
NCBI Official Symbol
STAR
NCBI Official Synonym Symbols
STARD1
NCBI Protein Information
steroidogenic acute regulatory protein, mitochondrial
UniProt Protein Name
Steroidogenic acute regulatory protein, mitochondrial
UniProt Gene Name
STAR
UniProt Synonym Gene Names
STARD1; StAR; StARD1
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Product Notes
The STAR star (Catalog #AAA214693) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The StAR (Steroidogenic Acute Regulator) (Leydig Cell Marker) reacts with Human. Others not known. and may cross-react with other species as described in the data sheet. AAA Biotech's StAR (Steroidogenic Acute Regulator) can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry). Researchers should empirically determine the suitability of the STAR star for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "StAR (Steroidogenic Acute Regulator), Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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