Mouse anti-Human TdT/DNA Nucleotidylexotransferase Monoclonal Antibody | anti-DNTT antibody

TdT/DNA Nucleotidylexotransferase (Acute Lymphoblastic Leukemia Marker)

Cat. Num. AAA215444

• Gene Names: DNTT; TDT
• Reactivity: Human
• Applications: Immunohistochemistry, ELISA
• Purity: Purified Ab with BSA and Azide at 200ug/ml or Purified Ab with BSA and Azide at 200ug/ml or Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
• Synonyms: TdT/DNA Nucleotidylexotransferase, Antibody; TdT/DNA Nucleotidylexotransferase (Acute Lymphoblastic Leukemia Marker); Deoxynucleotidyltransferase terminal; DNA Nucleotidylexotransferase; DNTT; Nucleosidetriphosphate DNA Deoxynucleotidylexotransferase; TDT; Terminal addition enzyme; Terminal deoxynucleotidyltransferase; Terminal deoxyribonucleotidyltransferase; Terminal transferase; anti-DNTT antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1, kappa
• Clone Number: DNTT/1453
• Specificity: Terminal deoxynucleotidyltransferase (TdT) is a DNA polymerase which catalyzes the addition of deoxyribonucleotides onto the 3 termini of DNA. The human TdT gene maps to chromosome 10q24.1 and encodes a 510 amino acid protein. Human TdT is synthesized as a single chain peptide that elicits a minor preference for incorporation of deoxyribonucleotides over ribonucleotides forming DNA strands. TdT is present in immature thymocytes, some bone marrow cells, transformed pre-B and pre-T cell lines, and leukemia cells.
• Purity/Purification: Purified Ab with BSA and Azide at 200ug/ml or Purified Ab with BSA and Azide at 200ug/ml or Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
• Form/Format: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
• Sequence Length: 508

• Applicable Applications for anti-DNTT antibody: IHC (Immunohistochemistry), ELISA
• Immunogen: Recombinant fragment (around aa 52-192) of Human DNTT protein (exact sequence is proprietary)
• Cellular Localization: Nucleus
• Hu-chromosome Location: 10q24.1
• Positive Control: Human thymus. Jurkat cells.
• Preparation and Storage: Antibody with azide: store at 2 to 8 degree C.; Antibody without azide: store at -20 to -80 degree C.; Antibody is stable for 24 months. Non-hazardous. No MSDS required.

IHC (Immunohistochemisry)

(Formalin-fixed, paraffin-embedded human Thymus stained with TdTMouse Monoclonal Antibody (DNTT/1453).)

IHC (Immunohiostchemistry)

(Formalin-fixed, paraffin-embedded human Thymus stained with TdTMouse Monoclonal Antibody (DNTT/1453).)

IHC (Immunohistochemistry)

(Formalin-fixed, paraffin-embedded human Thymus stained with TdTMouse Monoclonal Antibody (DNTT/1453).)

References

Faber J, et al. Arch Pathol Lab Med. 2000 Jan;124(1):92-7.

NCBI and Uniprot Product Information

• NCBI GI #: 63054852
• NCBI GeneID: 1791
• NCBI Accession #: NP_001017520.1
• NCBI GenBank Nucleotide #: NP_001017520.1
• UniProt Accession #: P04053
• Molecular Weight: 58kDa
• NCBI Official Full Name: DNA nucleotidylexotransferase isoform 2
• NCBI Official Synonym Full Names: DNA nucleotidylexotransferase
• NCBI Official Symbol: DNTT
• NCBI Official Synonym Symbols: TDT
• NCBI Protein Information: DNA nucleotidylexotransferase
• UniProt Protein Name: DNA nucleotidylexotransferase
• UniProt Gene Name: DNTT
• UniProt Synonym Gene Names: TDT; Terminal transferase
• UniProt Entry Name: TDT_HUMAN