Application Data
Mouse anti-Human TIE-2 Monoclonal Antibody | anti-TIE-2 antibody
Mouse Anti-Human TIE-2
Gene Names
TEK; TIE2; VMCM; TIE-2; VMCM1; CD202B
Reactivity
Human
Applications
Flow Cytometry, Functional Assay, Western Blot, ELISA
Purity
Protein G purified
Synonyms
TIE-2, Antibody; Mouse Anti-Human TIE-2; Anti-human TIE-2 (#tek9); Tyrosine kinase with Ig and EGF homology domain-2; anti-TIE-2 antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG1
Clone Number
IgG1; tek9
Specificity
The monoclonal antibody will detect native human TIE-2/tek in ELISA experiments and on the surface of different human cell types.
Purity/Purification
Protein G purified
Form/Format
Lyophilized
Sequence Length
1124
Applicable Applications for anti-TIE-2 antibody
FCM/FACS (Flow Cytometry), WB (Western Blot), ELISA
Immunogen
recombinant human soluble extracellular domain of TIE-2
Preparation
Monoclonal antibodies were produced with the help of BALB/c mice using recombinant human soluble extracellular domain of TIE-2.
Buffer
PBS
Preparation and Storage
The lyophilized antibody is stable at room temperature for up to 1 month. The reconstituted antibody is stable for at least two weeks at 2-8 degree C. Frozen aliquots are stable for at least 6 months when stored at -20 degree C.
Application Data
Application Data
Application Data
Application Data
Related Product Information for anti-TIE-2 antibody
Tie-1/Tie and Tie-2/Tek are receptor tyrosine kinases with unique structural characteristics including two immunoglobulin-like domains flanking three epidermal growth factor (EGF)-like domains, followed by three fibronectin type III-like repeats in the extracellular region, and a split tyrosine kinase domain in the cytoplasmic region. Tie-2 is involved in vascular stabilization and remodeling. Although less well understood, Tie-1 may also act as an ANG receptor, possibly in complex with Tie-2. Human Tie-2 cDNA encodes a 1124 amino acid (aa) residue precursor protein with an 18 residue putative signal peptide, a 727 residue extracellular domain and a 354 residue cytoplasmic domain. Tie-2 is a receptor for the angiopoietin (ANG) family: ANG-1, ANG-2, and ANG-3 (mouse)/-4 (human). Ang-2 has been reported to act as an antagonist for Ang-1. Mice engineered to overexpress Ang-2 or to lack Ang-1 or Tie-2 display similar angiogenesis defects.
References
1. Reusch et al., Angiogenesis 4:123, 2001 2. Harris et al., Clin Cancer Res. 7 :1992, 2001 3. Partanen J and DJ Dumont (1999) Curr Top Microbiol Immunol 237:159. 4. Takakura N et al, (1998) Immunity 9:677. 5. Procopio W et al, (1999) J Biol Chem 274:30196. 6. Sato et al. (1993) PNAS 90:9355 7.Gale et al., (1999) Gen Dev 13:1055 8. Van Hoof et al, J Proteome Res 9:1610, 2010
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
125,830 Da
NCBI Official Full Name
angiopoietin-1 receptor
NCBI Official Synonym Full Names
TEK tyrosine kinase, endothelial
NCBI Official Symbol
TEK
NCBI Official Synonym Symbols
TIE2; VMCM; TIE-2; VMCM1; CD202B
NCBI Protein Information
angiopoietin-1 receptor; hTIE2; p140 TEK; soluble TIE2 variant 1; soluble TIE2 variant 2; endothelial tyrosine kinase; tyrosine-protein kinase receptor TEK; tunica interna endothelial cell kinase; tyrosine-protein kinase receptor TIE-2; tyrosine kinase with Ig and EGF homology domains-2
UniProt Protein Name
Angiopoietin-1 receptor
UniProt Gene Name
TEK
UniProt Synonym Gene Names
TIE2; VMCM; VMCM1; hTIE2
UniProt Entry Name
TIE2_HUMAN
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Product Notes
The TIE-2 tek (Catalog #AAA79089) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Mouse Anti-Human TIE-2 reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's TIE-2 can be used in a range of immunoassay formats including, but not limited to, FCM/FACS (Flow Cytometry), WB (Western Blot), ELISA. Researchers should empirically determine the suitability of the TIE-2 tek for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TIE-2, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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