Application Data
(Human peripheral blood lymphocytes were stained with 0.2ug Purified Anti-Human TRAV12-1 Antibody[S511] (Right) and 0.2?g mouse IgG2b,? lsotype Control (Left), followed by Fluor® 647-conjugated goat Anti-mouse IgG Secondary Antibody, then anti-human CD3 PE-conjugated Monoclonal Antibody.)
Mouse anti-Human TRAV12-1 Monoclonal Antibody | anti-TRAV12-1 antibody
Purified Anti-Human TRAV12-1 Antibody [S511]
Reactivity
Human
Applications
Flow Cytometry, Functional Assay
Purity
>98% Protein A/G purified
Synonyms
TRAV12-1, Antibody; Purified Anti-Human TRAV12-1 Antibody [S511]; anti-TRAV12-1 antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
Mouse IgG2b, kappa
Clone Number
S511
Purity/Purification
>98% Protein A/G purified
Form/Format
Phosphate buffered solution, pH 7.2, containing 0.05% non-protein stabilizer. Dialyze to completely remove the stabilizer prior to labeling.
Applicable Applications for anti-TRAV12-1 antibody
FCM/FACS (Flow Cytometry)
Immunogen
Recombinant Human TRAV12-1 protein
Note
Centrifuge before opening to ensure complete recovery of vial contents.
Preparation and Storage
Store at 4 degree C valid for 12 months or -20 degree C valid for long term storage, avoid freeze/thaw cycles.
Application Data
(Human peripheral blood lymphocytes were stained with 0.2ug Purified Anti-Human TRAV12-1 Antibody[S511] (Right) and 0.2?g mouse IgG2b,? lsotype Control (Left), followed by Fluor® 647-conjugated goat Anti-mouse IgG Secondary Antibody, then anti-human CD3 PE-conjugated Monoclonal Antibody.)
Application Data
(Human peripheral blood lymphocytes were stained with 0.2ug Purified Anti-Human TRAV12-1 Antibody[S511] (Right) and 0.2?g mouse IgG2b,? lsotype Control (Left), followed by Fluor® 647-conjugated goat Anti-mouse IgG Secondary Antibody, then anti-human CD3 PE-conjugated Monoclonal Antibody.)
Related Product Information for anti-TRAV12-1 antibody
The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory autodestructive reactions and are believed to be a method by which the immune system compensates for disease (ref5). T Cell and TCR Diversity Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). A small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.
Product Categories/Family for anti-TRAV12-1 antibody
NCBI and Uniprot Product Information
UniProt Accession #
Similar Products
Product Notes
The TRAV12-1 (Catalog #AAA179732) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Purified Anti-Human TRAV12-1 Antibody [S511] reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's TRAV12-1 can be used in a range of immunoassay formats including, but not limited to, FCM/FACS (Flow Cytometry). Researchers should empirically determine the suitability of the TRAV12-1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TRAV12-1, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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