Mouse anti-Human XBP1 Monoclonal Antibody | anti-XBP1 antibody

Mouse monoclonal antibody Anti-Human XBP1

Cat. Num. AAA36350

• Gene Names: XBP1; XBP2; TREB5; XBP-1; TREB-5
• Reactivity: Human
• Applications: Dot Blot
• Synonyms: XBP1, Antibody; Mouse monoclonal antibody Anti-Human XBP1; X-box binding protein 1; XBP2; TREB5; anti-XBP1 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: XBP1H6E5
• Form/Format: Mouse monoclonal anti-human XBP1 antibody in PBS (3.0 mM KCl, 1.5mM KH₂HPO₄ 140mM NaCl, 8.0mM Na₂HPO₄ (pH 7.4)) containing 1% bovine serum albumin (BSA) and 0.05% sodium azide (NaN₃)
• Concentration: 100 ug/ml (1.0 ml) (varies by lot)
• Sequence Length: 1820

• Applicable Applications for anti-XBP1 antibody: DB (Dot Blot)
• Immunogen: Recombiant
• Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
• Sterility: Filtered through a 0.22 um membrane.
• Disposal: This antibody solution contains sodium azide (NaN₃) as a preservative. There is a potential hazard that NaN₃ reacts with copper or lead to produce an explosive compound. For safe disposal, the vial has to be washed thoroughly with water.
• Preparation and Storage: Store at 2-8°C for up to one year.; We recommend storing at -20°C for long-term storage.; Avoid repeat freezing and thawing cycles.

Quality Control #2

(Arrow indicates the region of immunized recombinant protein carrying 50-200 amino acids.)

Quality Control

(Western blot analysis of immunized recombinant protein, using anti-XBP1 monoclonal antibody.)

Related Product Information for anti-XBP1 antibody

This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein and was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has also been found that the same agents that cause an ER stress response, the unfolded protein response (UPR), also increase transcription of this gene. This increase in transcription requires an ER stress response consensus binding element in the promoter. In the UPR pathway, two isoforms of the protein are made. The function of the shorter isoform (XBP-1U) has not been determined, while the longer isoform (XBP-1S) is the active isoform. The longer isoform is generated by a process in which two adjecent stem loop structures in the mRNA are recognized by IRE1, resulting in the loss of 26 nt from the mRNA and a frameshift in the CDS. Finally, a pseudogene has been identified and localized to chromosome 5. [NCBI Entrez Gene Summary]

NCBI and Uniprot Product Information

• NCBI GI #: 172072591
• NCBI GeneID: 7494
• NCBI Accession #: NP_005071.2
• NCBI GenBank Nucleotide #: NM_005080
• Molecular Weight: 40,148 Da
• NCBI Official Full Name: Homo sapiens X-box binding protein 1 (XBP1), transcript variant 1, mRNA
• NCBI Official Synonym Full Names: X-box binding protein 1
• NCBI Official Symbol: XBP1
• NCBI Official Synonym Symbols: XBP2; TREB5; XBP-1; TREB-5
• NCBI Protein Information: X-box-binding protein 1; tax-responsive element-binding protein 5
• UniProt Protein Name: X-box-binding protein 1
• UniProt Gene Name: XBP1
• UniProt Entry Name: XBP1_HUMAN