Mouse anti-Human CD156c Antibody | anti-CD156c antibody

Anti-Hu CD156c APC

Cat. Num. AAA129372

• Gene Names: ADAM10; kuz; AD10; MADM; CD156c; HsT18717
• Reactivity: Human
• Applications: Flow Cytometry, Functional Assay
• Purity: Purified antibody is conjugated with activated allophycocyanin (APC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
• Synonyms: CD156c; N/A; Anti-Hu CD156c APC; ADAM metallopeptidase domain 10; ADAM10, AD10, RAK, MADM, HsT18717; anti-CD156c antibody

• Host: Mouse
• Reactivity: Human
• Isotype: Mouse IgG1 kappa
• Clone Number: 11G2
• Specificity: The mouse monoclonal antibody 11G2 recognizes an extracellular/luminal epitope of CD156c, a type I transmembrane glycoprotein, serving as a zinc-dependent metalloprotease.
• Purity/Purification: Purified antibody is conjugated with activated allophycocyanin (APC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
• Form/Format: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

• Applicable Applications for anti-CD156c antibody: FCM/FACS (Flow Cytometry)
• Negative Species: Mouse
• Immunogen: Jurkat cells
• Conjugation: APC
• Preparation and Storage: Store at 2-8 degree C. Protect from prolonged exposure to light. Do not freeze.

FCM/FACS (Flow Cytometry)

(Separation of human monocytes (red-filled) from CD156c negative blood debris (black-dashed) in flow cytometry analysis (surface staining) of human peripheral whole blood stained using anti-human CD156c (11G2) APC antibody (10ul reagent/100ul of peripheral whole blood).)

FCM/FACS (Flow Cytometry)

(Flow cytometry surface staining pattern of human peripheral whole blood stained using anti-human CD156c (11G2) APC antibody (10ul reagent/100ul of peripheral whole blood).)

Related Product Information for anti-CD156c antibody

CD156c is a type I transmembrane glycoprotein with a zinc-dependent metalloprotease activity. It serves as an endopeptidase of broad specificity, which is expressed mainly in thymus, liver, and muscles. Its expression can be induced in inflamed central nervous system, and in arthritic tissues. CD156c is involved in multiple sclerosis-associated myelin degradation. It also solubilizes various membrane proteins, including CD23, CD44, CD126, CD171, ephrin-A2, and other.

References

*Zola H et al.: Leukocyte and Stromal Cell Molecules, Wiley 2007, URL: ,*Arduise C, Abache T, Li L, Billard M, Chabanon A, Ludwig A, Mauduit P, Boucheix C, Rubinstein E, Le Naour F: Tetraspanins regulate ADAM10-mediated cleavage of TNF-alpha and epidermal growth factor. J Immunol. 2008 Nov 15;181(10):7002-13., URL: https://pubmed.ncbi.nlm.nih.gov/18981120/,*Saint-Pol J, Billard M, Dornier E, Eschenbrenner E, Danglot L, Boucheix C, Charrin S, Rubinstein E: New insights into the tetraspanin Tspan5 using novel monoclonal antibodies. J Biol Chem. 2017 Jun 9;292(23):9551-9566., URL: https://pubmed.ncbi.nlm.nih.gov/28428248/,

NCBI and Uniprot Product Information

• NCBI GI #: 2393947
• NCBI GeneID: 102
• UniProt Accession #: O14672; Q10742; Q92650
• Molecular Weight: 84,142 Da
• NCBI Official Full Name: ADAM10
• NCBI Official Synonym Full Names: ADAM metallopeptidase domain 10
• NCBI Official Symbol: ADAM10
• NCBI Official Synonym Symbols: kuz; AD10; MADM; CD156c; HsT18717
• NCBI Protein Information: disintegrin and metalloproteinase domain-containing protein 10; CDw156; ADAM 10; kuzbanian protein homolog; mammalian disintegrin-metalloprotease; a disintegrin and metalloprotease domain 10; a disintegrin and metalloproteinase domain 10
• UniProt Protein Name: Disintegrin and metalloproteinase domain-containing protein 10
• UniProt Gene Name: ADAM10
• UniProt Synonym Gene Names: KUZ; MADM; ADAM 10
• UniProt Entry Name: ADA10_HUMAN