Rabbit ABCC4 Polyclonal Antibody | anti-ABCC4 antibody

ABCC4 Antibody

Cat. Num. AAA306425

• Gene Names: ABCC4; MRP4; MOATB; MOAT-B
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry, Western Blot
• Purity: Antibodies were purified by affinity purification using immunogen.
• Synonyms: ABCC4, Antibody; ABCC4 Antibody; EST170205; MOAT-B; MOATB; MRP4; anti-ABCC4 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous level of total ABCC4 protein.
• Purity/Purification: Antibodies were purified by affinity purification using immunogen.
• Form/Format: Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1.0 mg/ml (varies by lot)
• Sequence Length: 859

• Applicable Applications for anti-ABCC4 antibody: IHC (Immunohistochemistry), WB (Western Blot)
• Immunogen Type: Recombinant Protein
• Immunogen Description: Recombinant protein of human ABCC4.
• Target Name: ABCC4
• Preparation and Storage: Store at -20 degree C

IHC (Immunohistochemisry)

(Immunohistochemical analysis of paraffin-embedded human esophagus using ABCC4 antibody at dilution of 1:200 (200x lens).)

IHC (Immunohiostchemistry)

(Immunohistochemical analysis of paraffin-embedded human esophageal cancer using ABCC4 antibody at dilution of 1:200 (200x lens).)

WB (Western Blot)

(Western blot analysis of extracts of kindney cell line, using ABCC4 antibody.)

Related Product Information for anti-ABCC4 antibody

ABCC4 is a member of the ATP-binding Cassette (ABC) transporter family. ABC proteins transport various molecules across cellular membranes by utilizing the energy generated from ATP hydrolysis. There are seven subfamilies of ABC proteins: ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White (1). ABCC4 belongs to the MRP subfamily, which is involved in multi-drug resistance, hence it is also named MRP4. ABCC4 is widely expressed in cells and tissues including prostate, kidney proximal tubules, astrocytes and capillary endothelial cells of the brain, platelets, and many cancer cell lines (2-4). ABCC4 mediates efflux transport of a wide variety of endogenous and xenobiotic organic anionic compounds (5). The diversity of substrates determines the biological functions of ABCC4. It regulates cAMP levels in human leukemia cells, thereby controlling the proliferation and differentiation of leukemia cells (6). ABCC4 also enables COX deficient pancreatic cancer cells to obtain exogenous prostagladins (7). Researchers have shown that ABCC4 expression is elevated in drug resistant cancer cells, which makes it a potential target for cancer therapy (8,9). ABCC4 localizes to both plasma membrane and intracellular membranous structures (10). Investigators have also implicated ABCC4 in the pathogenesis of Kawasaki desease, a genetic childhood disease characterized by vasculitis (11).

Product Categories/Family for anti-ABCC4 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 157502203
• NCBI GeneID: 10257
• NCBI Accession #: NP_001098985.1
• NCBI GenBank Nucleotide #: NM_001105515.2
• UniProt Accession #: O15439; Q8IVZ4; Q8IZN6; Q8NEW8; Q9Y6J2; A9Z1Z7; B7Z3Q7
• Molecular Weight: 88,138 Da
• NCBI Official Full Name: multidrug resistance-associated protein 4 isoform 2
• NCBI Official Synonym Full Names: ATP-binding cassette, sub-family C (CFTR/MRP), member 4
• NCBI Official Symbol: ABCC4
• NCBI Official Synonym Symbols: MRP4; MOATB; MOAT-B
• NCBI Protein Information: multidrug resistance-associated protein 4
• UniProt Protein Name: Multidrug resistance-associated protein 4
• UniProt Gene Name: ABCC4
• UniProt Synonym Gene Names: MRP4; MOAT-B
• UniProt Entry Name: MRP4_HUMAN