Rabbit anti-Human, Mouse AGER Polyclonal Antibody | anti-AGER antibody

AGER Antibody

Cat. Num. AAA170365

• Gene Names: AGER; RAGE
• Reactivity: Human, Mouse
• Applications: Immunohistochemistry, Western Blot
• Purity: Antigen affinity purification
• Synonyms: AGER, Antibody; AGER Antibody; MGC22357; RAGE; AGER; anti-AGER antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen affinity purification
• Concentration: 1mg/mL (varies by lot)
• Sequence Length: 347

• Applicable Applications for anti-AGER antibody: IHC (Immunohistochemistry), WB (Western Blot)
• Immunogen: Recombinant protein of human AGER
• Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• Preparation and Storage: Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.

IHC (Immunohiostchemistry)

(Immunohistochemistry of paraffin-embedded human esophageal cancer using AGER antibody at dilution of 1:200 (x400 lens).)

WB (Western Blot)

(Western blot analysis of extracts of various tissues, using AGER antibody.)

Related Product Information for anti-AGER antibody

The receptor for advanced glycation end products (RAGE) is member of the immunoglobulin (Ig) superfamily. It can be expressed as full-length, membrane-bound RAGE isoform 1 or as a secreted sRAGE protein that lacks a transmembrane domain (1). RAGE is detected during early developmental stages and in the lung under normal physiological conditions (2) and is upregulated at sites of inflammation (3). Advanced glycation end products (AGEs) and a variety of other ligands interact with this receptor (1). Ligand binding activates full-length RAGE and initiates downstream signaling pathways that include activation of NF-kappaB, which leads to production of pro-inflammatory cytokines and inflammation (4). Activation of these pathways has been implicated in various disease states including Alzheimer disease, diabetes, arthritis, and atherosclerosis (4). Soluble RAGE can competitively bind RAGE ligands in the extracellular environment, which prevents ligand interaction with full-length RAGE at the cell surface (1).

NCBI and Uniprot Product Information

• NCBI GI #: 332800988
• NCBI GeneID: 177
• NCBI Accession #: NP_001193895.1
• NCBI GenBank Nucleotide #: NM_001206966.1
• Molecular Weight: 41,098 Da
• NCBI Official Full Name: advanced glycosylation end product-specific receptor isoform 6
• NCBI Official Synonym Full Names: advanced glycosylation end product-specific receptor
• NCBI Official Symbol: AGER
• NCBI Official Synonym Symbols: RAGE
• NCBI Protein Information: advanced glycosylation end product-specific receptor; RAGE isoform NtRAGE-delta; RAGE isoform sRAGE-delta; receptor for advanced glycation end-products variant 20
• UniProt Protein Name: Advanced glycosylation end product-specific receptor
• UniProt Gene Name: AGER
• UniProt Synonym Gene Names: RAGE
• UniProt Entry Name: RAGE_HUMAN