Rabbit Aipl1 Polyclonal Antibody | anti-AIPL1 antibody

Aipl1 Antibody

Cat. Num. AAA40007

• Gene Names: AIPL1; LCA4; AIPL2
• Reactivity: Human, Mouse, Rat
• Applications: Immunofluorescence, Immunohistochemistry, Western Blot, ELISA
• Purity: Aipl1 Antibody is affinity chromatography purified via peptide column.
• Synonyms: Aipl1, Antibody; Aipl1 Antibody; Aipl1; LCA4; AIPL2; Aryl-hydrocarbon-interacting protein-like 1; aryl hydrocarbon receptor interacting protein-like 1; anti-AIPL1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Aipl1 Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 384

• Applicable Applications for anti-AIPL1 antibody: IF (Immunofluorescence), IHC (Immunohistochemistry), WB (Western Blot), ELISA
• Conjugate: Unconjugated
• Immunogen: Aipl1 antibody was raised against a 18 amino acid synthetic peptide near the center of the human Aipl1.
• Buffer: Aipl1 Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: Aipl1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IF (Immunofluorescence)

(Immunofluorescence of aipl1 in human brain tissue with aipl1 antibody at 20 μg/mL.)

IHC (Immunohiostchemistry)

(Immunohistochemistry of Aipl1 in human brain tissue with Aipl1 antibody at 2.5 μg/mL.)

WB (Western Blot)

(Western blot analysis of Aipl1 in rat brain tissue lysate with Aipl1 antibody at (A) 1 and (B) 2 μg/mL.)

Related Product Information for anti-AIPL1 antibody

Aipl1 Antibody: Aipl1 was initially identified as a protein implicated in Leber congenital amaurosis (LCA), an autosomal recessive disorder thought to be caused by the abnormal development of photoreceptors. Aipl1 is a tetratricopeptide repeat protein that is highly homologous to ARA9, a protein involved in the HSP90-mediated nuclear translocation and transactivation of the aryl hydrocarbon receptor. Aipl1 has also been found to function as part of a chaperone heterocomplex, interacting with Hsp90 and Hsp70. Aipl1 also associates with the cell cycle regulator NUB1. It is thought that Aipl1 cooperates with Hsp70 but not Hsp90 to suppress the formation of NUB1 inclusions, and these interactions are necessary in the normal photoreceptor maturation, as mutations that lead to LCA also compromise the interactions with the Hsp chaperones. At least three isoforms of Aipl1 are known to exist.

NCBI and Uniprot Product Information

• NCBI GI #: 74272276
• NCBI GeneID: 23746
• NCBI Accession #: NP_055151
• NCBI GenBank Nucleotide #: NM_014336.4
• UniProt Accession #: Q9NZN9; Q659W3; Q659W4; Q6ZZB6; Q8N6A0; Q9H873; Q9NS10; D3DTM4
• Molecular Weight: 40,901 Da
• NCBI Official Full Name: aryl-hydrocarbon-interacting protein-like 1 isoform 1
• NCBI Official Synonym Full Names: aryl hydrocarbon receptor interacting protein-like 1
• NCBI Official Symbol: AIPL1
• NCBI Official Synonym Symbols: LCA4; AIPL2
• NCBI Protein Information: aryl-hydrocarbon-interacting protein-like 1
• UniProt Protein Name: Aryl-hydrocarbon-interacting protein-like 1
• UniProt Gene Name: AIPL1
• UniProt Synonym Gene Names: AIPL2
• UniProt Entry Name: AIPL1_HUMAN