Rabbit anti-Human AP-2 complex subunit alpha-1 Polyclonal Antibody | anti-AP2A1 antibody

Rabbit anti-human AP-2 complex subunit alpha-1 polyclonal Antibody(AP2A1)

Cat. Num. AAA119611

• Gene Names: AP2A1; ADTAA; CLAPA1; AP2-ALPHA
• Reactivity: Human
• Applications: Immunohistochemistry, ELISA
• Purity: Antigen Affinity Purified
• Synonyms: AP-2 complex subunit alpha-1, Antibody; Rabbit anti-human AP-2 complex subunit alpha-1 polyclonal Antibody(AP2A1); 100 kDa coated vesicle protein A; Adaptor protein complex AP-2 subunit alpha-1; Adaptor-related protein complex 2 subunit alpha-1; Alpha-adaptin A; Alpha1-adaptin; Clathrin assembly protein complex 2 alpha-A large chain; Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit; AP2A1; ADTAA; CLAPA1; anti-AP2A1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 977

• Applicable Applications for anti-AP2A1 antibody: IHC (Immunohistochemistry), ELISA
• Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Conjugate: Non-conjugated
• Immunogen: Recombinant human AP-2 complex subunit alpha-1 protein (1-260aa)
• Species: Human
• Research Area: Signal Transduction
• Target Names: AP2A1
• Preparation and Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

IHC (Immunohiostchemistry)

(Immunohistochemistry of paraffin-embedded human placenta using AAA119611 at dilution 1:100)

IHC (Immunohistochemistry)

(Immunohistochemistry of paraffin-embedded human prostate using AAA119611 at dilution 1:100)

Related Product Information for anti-AP2A1 antibody

Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif (By similarity).

NCBI and Uniprot Product Information

• NCBI GI #: 19913414
• NCBI GeneID: 160
• NCBI Accession #: NP_055018.2
• NCBI GenBank Nucleotide #: NM_014203.2
• UniProt Accession #: O95782; Q96CI7; Q96PP6; Q96PP7; Q9H070
• NCBI Official Full Name: AP-2 complex subunit alpha-1 isoform 1
• NCBI Official Synonym Full Names: adaptor related protein complex 2 alpha 1 subunit
• NCBI Official Symbol: AP2A1
• NCBI Official Synonym Symbols: ADTAA; CLAPA1; AP2-ALPHA
• NCBI Protein Information: AP-2 complex subunit alpha-1
• UniProt Protein Name: AP-2 complex subunit alpha-1
• UniProt Gene Name: AP2A1
• UniProt Synonym Gene Names: ADTAA; CLAPA1
• UniProt Entry Name: AP2A1_HUMAN