Rabbit anti-Human ATM Polyclonal Antibody | anti-ATM antibody

ATM Antibody

Cat. Num. AAA306580

• Gene Names: ATM; AT1; ATA; ATC; ATD; ATE; ATDC; TEL1; TELO1
• Reactivity: Human
• Applications: Immunohistochemistry, Western Blot, ELISA
• Purity: Affinity chromatography purified via peptide column
• Synonyms: ATM, Antibody; ATM Antibody; mutated in Ataxia-Telangiectasia; anti-ATM antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Purity/Purification: Affinity chromatography purified via peptide column
• Form/Format: Supplied in PBS containing 0.02% sodium azide.
• Sequence Length: 3056

• Applicable Applications for anti-ATM antibody: IHC (Immunohistochemistry), WB (Western Blot), ELISA
• Immunogen Type: Peptide
• Immunogen Description: Raised against a peptide corresponding to 14 amino acids near the carboxy terminus of human ATM.
• Target Name: ATM
• Preparation and Storage: Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IHC (Immunohiostchemistry)

(Immunohistochemistry of ATM in human lymph node tissue with ATM antibody at 2.5 ug/mL.)

WB (Western Blot)

(Western blot analysis of ATM in Daudi whole cell lysate with ATM antibody at (A) 1 and (B) 2 ug/mL.)

Related Product Information for anti-ATM antibody

DNA double strand breaks represent a major threat to an organism's genome. Eukaryotic cells have developed mechanisms that sense the presence this damage and initiate suitable responses that can include DNA repair, cell cycle delay, and programmed cell death. The ATM (mutated in Ataxia-Telangiectasia) protein kinase is activated following the formation of DNA double strand breaks, phosphorylating p53 and another kinase CHK2. This initiates a signaling cascade leading to the phosphorylation and inhibition of Cdc25, ultimately preventing cell cycle progression. In some cell types, such as the hemapoietic system, this leads to apoptosis instead of cell cycle arrest. Multiple isoforms of ATM are known to exist.

Product Categories/Family for anti-ATM antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 2304971
• NCBI GeneID: 472
• Molecular Weight: 350,687 Da
• NCBI Official Full Name: ATM
• NCBI Official Synonym Full Names: ATM serine/threonine kinase
• NCBI Official Symbol: ATM
• NCBI Official Synonym Symbols: AT1; ATA; ATC; ATD; ATE; ATDC; TEL1; TELO1
• NCBI Protein Information: serine-protein kinase ATM
• UniProt Protein Name: Serine-protein kinase ATM
• UniProt Gene Name: ATM
• UniProt Synonym Gene Names: A-T mutated
• UniProt Entry Name: ATM_HUMAN