ICC (Immunocytochemistry)
(Immunocytochemistry of BACE in 3T3 cells with BACE antibody at 10 ug/mL.)
Rabbit anti-Human, Mouse BACE Polyclonal Antibody | anti-BACE antibody
BACE Antibody
Gene Names
BACE1; ASP2; BACE; HSPC104
Reactivity
Human, Mouse
Applications
Immunocytochemistry, Western Blot, ELISA
Purity
Ion exchange chromatography purified
Synonyms
BACE, Antibody; BACE Antibody; Asp; anti-BACE antibody
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Purity/Purification
Ion exchange chromatography purified
Form/Format
Supplied in PBS containing 0.02% sodium azide.
Sequence Length
2526
Applicable Applications for anti-BACE antibody
ICC (Immunocytochemistry), WB (Western Blot), ELISA
Immunogen Type
Peptide
Immunogen Description
Raised against a peptide corresponding to 17 amino acids at the carboxy terminus of human BACE.
Target Name
BACE
Preparation and Storage
Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
ICC (Immunocytochemistry)
(Immunocytochemistry of BACE in 3T3 cells with BACE antibody at 10 ug/mL.)
ICC (Immunocytochemistry)
(Immunocytochemistry of BACE in 3T3 cells with BACE antibody at 10 ug/mL.)
WB (Western Blot)
(Western blot analysis of BACE in human brain tissue lysate in the absence (A) or presence (B) of blocking peptide (2253P) and in mouse 3T3 cell lysate (C) with BACE antibody at 1 ug/mL.)
WB (Western Blot)
(Western blot analysis of BACE in human brain tissue lysate in the absence (A) or presence (B) of blocking peptide (2253P) and in mouse 3T3 cell lysate (C) with BACE antibody at 1 ug/mL.)
Related Product Information for anti-BACE antibody
Accumulation of the amyloid-beta (Abeta) plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. Abeta peptide is generated by proteolytic cleavage of the beta-amyloid protein precursor (APP) at beta- and gamma-sites by two proteases. APP is first cleaved by beta-secretase, producing a soluble derivative of the protein and a membrane anchored 99-amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for gamma-secretase to generate the 4 kDa amyloid-beta peptide, which is deposited in the brains of all suffers of Alzheimer's disease. The long-sought beta-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2). BACE/Asp2 is a novel transmembrane aspartic protease and colocalizes with APP.
Product Categories/Family for anti-BACE antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
42,107 Da
NCBI Official Full Name
Homo sapiens beta-site APP cleaving enzyme (BACE) mRNA, complete cds
NCBI Official Synonym Full Names
beta-site APP-cleaving enzyme 1
NCBI Official Symbol
BACE1
NCBI Official Synonym Symbols
ASP2; BACE; HSPC104
NCBI Protein Information
beta-secretase 1
UniProt Protein Name
Beta-secretase 1
UniProt Gene Name
BACE1
UniProt Synonym Gene Names
BACE; KIAA1149; ASP2; Asp 2; Beta-site APP cleaving enzyme 1
UniProt Entry Name
BACE1_HUMAN
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Product Notes
The BACE bace1 (Catalog #AAA305920) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The BACE Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's BACE can be used in a range of immunoassay formats including, but not limited to, ICC (Immunocytochemistry), WB (Western Blot), ELISA. Researchers should empirically determine the suitability of the BACE bace1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "BACE, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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