IHC (Immunohiostchemistry)
(Fig: 2 Formalin-fixed paraffin-embedded human tissue for Bak expression using at 1: 2000. A. Ductal breast carcinoma. B. Lymphocyte infiltration in soft tissue adjacent to colon carcinoma. Hematoxylin-eosin counterstain.)
Rabbit anti-Mouse, Human BAK Polyclonal Antibody | anti-BAK1 antibody
Polyclonal Antibody to BAK
Gene Names
BAK1; BAK; CDN1; BCL2L7; BAK-LIKE
Reactivity
Mouse, Human
Applications
Western Blot, Immunohistochemistry, Immunoprecipitation
Purity
Serum
Synonyms
BAK, Antibody; Polyclonal Antibody to BAK; BAK1; BAK; BCL2L7; CDN1; Apoptosis regulator BAK; Bcl2-L-7; Bcl-2-like protein 7; Antibody to BAK; Anti-BAK Antibody; BAK Antibody; anti-BAK1 antibody
Host
Rabbit
Reactivity
Mouse, Human
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Serum
Form/Format
50 ul sera
Sequence Length
211
Applicable Applications for anti-BAK1 antibody
WB (Western Blot), IHC (Immunohistochemistry), IP (Immunoprecipitation)
Immunogen Information
A synthetic peptide of BAK protein (amino acids 16-36 EPALPSASEEQVAQDTEEVFR) was used as the immunogen for this antibody
Antigen
BAK
Preparation and Storage
Store the antibody at 4 degree C, stable for 6 months.
For long-term storage, store at -20 degree C.
Avoid repeated freeze and thaw cycles.
For long-term storage, store at -20 degree C.
Avoid repeated freeze and thaw cycles.
IHC (Immunohiostchemistry)
(Fig: 2 Formalin-fixed paraffin-embedded human tissue for Bak expression using at 1: 2000. A. Ductal breast carcinoma. B. Lymphocyte infiltration in soft tissue adjacent to colon carcinoma. Hematoxylin-eosin counterstain.)
IHC (Immunohiostchemistry)
(Fig: 2 Formalin-fixed paraffin-embedded human tissue for Bak expression using at 1: 2000. A. Ductal breast carcinoma. B. Lymphocyte infiltration in soft tissue adjacent to colon carcinoma. Hematoxylin-eosin counterstain.)
IHC (Immunohistochemistry)
(Fig: 1 Formalin-fixed paraffin-embedded tissue sections of human heart with cardiomyopathy stained for Bak expression using at 1: 2000 (A and B). Hematoxylin-eosin counterstain.)
IHC (Immunohistochemistry)
(Fig: 1 Formalin-fixed paraffin-embedded tissue sections of human heart with cardiomyopathy stained for Bak expression using at 1: 2000 (A and B). Hematoxylin-eosin counterstain.)
Related Product Information for anti-BAK1 antibody
Human BAK is a 211 amino acid protein. The Bcl-2 family of apoptosis-related genes plays central roles in regulating apoptotic pathways. Bcl-2 family proteins can be divided into 3 main subfamilies on the basis of their function and the content of their Bcl-2 homology (BH) domains, for example: 1) Prosurvival: Bcl-2, Bcl-XL, Bcl-W, A1, and Mcl-1 2) Proapoptotic (multidomain): Bax, Bak, and Bok. 3) BH3-only (proapoptotic): Bad, Bcl-XS, Bid, Bik, Bim, Blk, Bmf, Bnip, Noxa, and Puma. Regulation of cell death through apoptosis is critical for the maintenance of homeostasis, defense against infectious agents, and normal development. Bcl-2 family proteins regulate apoptosis primarily through the regulation of mitochondrial outer membrane permeability. In mammals, the family consists of both prosurvival (antiapoptotic) and proapoptotic (prodeath) members. Cellular homeostasis is thought to be dependent on a balance between the actions of prosurvival and proapoptotic proteins. Many Bcl-2 family proteins are differentially expressed in various malignancies and some are useful prognostic biomarkers. Prosurvival proteins are often elevated in diverse cancers and have the potential to confer resistance to both endogenous cell death stimuli and cancer treatments. Alterations in the ratio or levels of Bcl-2 family proteins have been also associated with nonmalignant diseases including neurodegenerative diseases, autoimmune diseases, AIDs, Downs syndrome, cardiovascular diseases, diabetes, glomerulonephritis, and muscular dystrophy.
Product Categories/Family for anti-BAK1 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
16,872 Da
NCBI Official Full Name
Bcl-2 homologous antagonist/killer
NCBI Official Synonym Full Names
BCL2 antagonist/killer 1
NCBI Official Symbol
BAK1
NCBI Official Synonym Symbols
BAK; CDN1; BCL2L7; BAK-LIKE
NCBI Protein Information
bcl-2 homologous antagonist/killer
UniProt Protein Name
Bcl-2 homologous antagonist/killer
UniProt Gene Name
BAK1
UniProt Synonym Gene Names
BAK; BCL2L7; CDN1; Bcl2-L-7
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Product Notes
The BAK1 bak1 (Catalog #AAA78305) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Polyclonal Antibody to BAK reacts with Mouse, Human and may cross-react with other species as described in the data sheet. AAA Biotech's BAK can be used in a range of immunoassay formats including, but not limited to, WB (Western Blot), IHC (Immunohistochemistry), IP (Immunoprecipitation). Researchers should empirically determine the suitability of the BAK1 bak1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "BAK, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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