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IHC (Immunohistochemistry)
(Immunochemical staining of human CTNNB1 in human breast cancer (from 2 donors) with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections). Positive staining was localized to epithelium.)
Rabbit anti-Human beta-Catenin Polyclonal Antibody | anti-CTNNB1 antibody
Anti-beta-Catenin Antibody, Rabbit Polyclonal
Gene Names
CTNNB1; CTNNB; MRD19; armadillo
Reactivity
Human
Applications
Immunohistochemistry, ELISA
Purity
Protein A & Antigen Affinity
Synonyms
beta-Catenin, Antibody; Anti-beta-Catenin Antibody, Rabbit Polyclonal; beta-Catenin/CTNNB1 Antibody, Rabbit PAb, Antigen Affinity Purified; catenin beta 1; Anti-armadillo Antibody; Anti-CTNNB Antibody; Anti-MRD19 Antibody; anti-CTNNB1 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
Human beta-Catenin/CTNNB1
Purity/Purification
Protein A & Antigen Affinity
Form/Format
Liquid; 0.2um filtered solution in PBS
Applicable Applications for anti-CTNNB1 antibody
IHC (Immunohistochemistry), ELISA
Immunogen
Recombinant Human beta-Catenin/CTNNB1 protein
Conjugation
Unconjugated
Preparation
Produced in rabbits immunized with purified, recombinant Human beta-Catenin/CTNNB1 (rh beta-Catenin/CTNNB1). beta-Catenin/CTNNB1 specific IgG was purified by Human beta-Catenin/CTNNB1 affinity chromatography.
Preparation and Storage
This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.
IHC (Immunohistochemistry)
(Immunochemical staining of human CTNNB1 in human breast cancer (from 2 donors) with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections). Positive staining was localized to epithelium.)
IHC (Immunohistochemistry)
(Immunochemical staining of human CTNNB1 in human breast cancer (from 2 donors) with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections). Positive staining was localized to epithelium.)
IHC (Immunohistochemisry)
(Immunochemical staining of human CTNNB1 in human colon cancer with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections). Positive staining was localized to colonic gland.)
IHC (Immunohistochemisry)
(Immunochemical staining of human CTNNB1 in human colon cancer with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections). Positive staining was localized to colonic gland.)
IHC (Immunohiostchemistry)
(Immunochemical staining of human CTNNB1 in human colon with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections). Positive staining was localized to colonic gland.)
IHC (Immunohiostchemistry)
(Immunochemical staining of human CTNNB1 in human colon with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections). Positive staining was localized to colonic gland.)
IHC (Immunohistochemistry)
(Immunochemical staining of human CTNNB1 in human skin (from 2 donors) with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections). Positive staining was localized to epithelium.)
IHC (Immunohistochemistry)
(Immunochemical staining of human CTNNB1 in human skin (from 2 donors) with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections). Positive staining was localized to epithelium.)
Related Product Information for anti-CTNNB1 antibody
beta-Catenin, also known as CTNNB1, is a member of the armadillo family of proteins. These proteins have multiple copies of the so-called armadillo repeat domain, which is specialized for protein-protein binding. It is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. CTNNB1 also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, beta-Catenin binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Defects in beta-Catenin can cause colorectal cancer, pilomatrixoma (PTR), medulloblastoma, and ovarian cancer. CTNNB1 is a key dowstream component of the canonical Wnt signaling pathway. In the absence of Wnt, it forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, beta-Catenin is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. CTNNB1 is involved in the regulation of cell adhesion. The majority of beta-catenin is localized to the cell membrane and is part of E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton.
Product Categories/Family for anti-CTNNB1 antibody
References
Yang, et al. (2002) Linking beta-catenin to androgen-signaling pathway. J Biol Chem. 277(13):11336-44.Hino S, et al. (2005) Phosphorylation of beta-Catenin by Cyclic AMP-Dependent Protein Kinase Stabilizes beta-Catenin through Inhibition of Its Ubiquitination. Mol Cell Biol. 25(20):9063-72.Liu X, et al. (2005) Rapid, Wnt-induced changes in GSK3beta associations that regulate beta-catenin stabilization are mediated by Galpha proteins. Curr Biol. 15(22):1989-97.Kraus C, et al. (1994) Localization of the human beta-catenin gene (CTNNB1) to 3p21: a region implicated in tumor development. Genomics. 23(1):272-4.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
85,497 Da
NCBI Official Full Name
catenin beta-1
NCBI Official Synonym Full Names
catenin (cadherin-associated protein), beta 1, 88kDa
NCBI Official Symbol
CTNNB1
NCBI Official Synonym Symbols
CTNNB; MRD19; armadillo
NCBI Protein Information
catenin beta-1
UniProt Protein Name
Catenin beta-1
UniProt Gene Name
CTNNB1
UniProt Synonym Gene Names
CTNNB
UniProt Entry Name
CTNB1_HUMAN
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Product Notes
The CTNNB1 ctnnb1 (Catalog #AAA255386) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-beta-Catenin Antibody, Rabbit Polyclonal reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's beta-Catenin can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), ELISA. Researchers should empirically determine the suitability of the CTNNB1 ctnnb1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "beta-Catenin, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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