WB (Western Blot)
(CABP1 Antibody (C-term) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the CABP1 antibody detected the CABP1 protein (arrow).)
Rabbit CABP1 Polyclonal Antibody | anti-CABP1 antibody
CABP1 Antibody (C-term)
Gene Names
CABP1; CALBRAIN; HCALB_BR
Reactivity
Human, mouse (Predicted Reactivity: Bovine, Rat)
Applications
Immunohistochemistry, ELISA, Western Blot
Purity
Purified Rabbit Polyclonal Antibody (Pab)
Synonyms
CABP1, Antibody; CABP1 Antibody (C-term); Calcium-binding protein 1; CaBP1; Calbrain; Caldendrin; CABP1; anti-CABP1 antibody
Host
Rabbit
Reactivity
Human, mouse (Predicted Reactivity: Bovine, Rat)
Clonality
Polyclonal
Isotype
Rabbit Ig
Specificity
This CABP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 311-343 amino acids from the C-terminal region of human CABP1.
Purity/Purification
Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Concentration
Vial Concentration: 2 (varies by lot)
Sequence Positions
311-343
Sequence Length
70
Applicable Applications for anti-CABP1 antibody
IHC (Immunohistochemistry), ELISA, WB (Western Blot)
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN
Function
Modulates calcium-dependent activity of inositol 1,4,5- triphosphate receptors (ITPRs)(PubMed: ). Inhibitsagonist- induced intracellular calcium signaling (PubMed: ). Enhances inactivation and does not support calcium-dependent facilitation of voltage-dependent P/Q-type calcium channels (PubMed: ). Causes calcium-dependent facilitation and inhibits inactivation of L-type calcium channels by binding to the same sites as calmodulin in the C- terminal domain of CACNA1C, but has an opposite effect on channel function (PubMed: ). Suppresses the calcium-dependent inactivation of CACNA1D (By similarity). Inhibits TRPC5 channels (PubMed: ). Prevents NMDA receptor-induced cellular degeneration. Required for the normal transfer of light signals through the retina (By similarity).
Cellular Location
Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Cell membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus Cell junction, synapse, postsynaptic density. Note=L- CaBP1 is associated most likely with the cytoskeletal structures, whereas S-CaBP1 is localized at or near the plasma membrane [Isoform S-CaBP1]: Cytoplasm, cell cortex. Cell membrane; Lipid-anchor Note=S-CaBP1 is localized at or near the plasma membrane
Tissue Location
Retina and brain. Somatodendritic compartment of neurons. Calbrain was found exclusively in brain where it is abundant in the hippocampus, habenular area in the epithalamus and in the cerebellum.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 2 weeks. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
WB (Western Blot)
(CABP1 Antibody (C-term) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the CABP1 antibody detected the CABP1 protein (arrow).)
WB (Western Blot)
(CABP1 Antibody (C-term) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the CABP1 antibody detected the CABP1 protein (arrow).)
IHC (Immunohiostchemistry)
(Formalin-fixed and paraffin-embedded human brain tissue reacted with CABP1 antibody (C-term) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.)
IHC (Immunohiostchemistry)
(Formalin-fixed and paraffin-embedded human brain tissue reacted with CABP1 antibody (C-term) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.)
WB (Western Blot)
(Western blot analysis of anti-CABP1 Antibody (C-term) in mouse cerebellum tissue lysates (35ug/lane).CABP1(arrow) was detected using the purified Pab.)
WB (Western Blot)
(Western blot analysis of anti-CABP1 Antibody (C-term) in mouse cerebellum tissue lysates (35ug/lane).CABP1(arrow) was detected using the purified Pab.)
Related Product Information for anti-CABP1 antibody
CABP1 belongs to a subfamily of calcium binding proteins, which share similarity to calmodulin. Calcium binding proteins are an important component of calcium mediated cellular signal transduction. Expression of this protein was only detected in retina and brain. Study of the mouse homolog demonstrated that groups of cells expressing this protein are located in the center or inner border of the inner unclear layer of retina.
Product Categories/Family for anti-CABP1 antibody
References
Haynes,L.P., Proteomics 6 (6), 1822-1832 (2006) Wingard,J.N., J. Biol. Chem. 280 (45), 37461-37470 (2005) Zhou,H., J. Biol. Chem. 280 (33), 29612-29619 (2005) Haeseleer,F., J. Biol. Chem. 275 (2), 1247-1260 (2000)
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
39838
NCBI Official Full Name
calcium-binding protein 1 isoform 3
NCBI Official Synonym Full Names
calcium binding protein 1
NCBI Official Symbol
CABP1
NCBI Official Synonym Symbols
CALBRAIN; HCALB_BR
NCBI Protein Information
calcium-binding protein 1
UniProt Protein Name
Calcium-binding protein 1
UniProt Gene Name
CABP1
UniProt Synonym Gene Names
CaBP1
UniProt Entry Name
CABP1_HUMAN
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Product Notes
The CABP1 cabp1 (Catalog #AAA287891) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 311-343. The CABP1 Antibody (C-term) reacts with Human, mouse (Predicted Reactivity: Bovine, Rat) and may cross-react with other species as described in the data sheet. AAA Biotech's CABP1 can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), ELISA, WB (Western Blot). Researchers should empirically determine the suitability of the CABP1 cabp1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CABP1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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