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Application Data
(Western blotting of Jurkat cell lysate probed with Rabbit anti Human CD294 (AAA50092))
Rabbit CD294 Polyclonal Antibody | anti-CD294 antibody
RABBIT ANTI HUMAN CD294 (N-TERMINAL)
Gene Names
Ptgdr2; Crth2; Gpr44; Grp45
Reactivity
Mouse (Expected from Sequence), Rat (Expected from Sequence)
Applications
Western Blot, Immunohistochemistry, ELISA
Synonyms
CD294, Antibody; RABBIT ANTI HUMAN CD294 (N-TERMINAL); anti-CD294 antibody
Host
Rabbit
Reactivity
Mouse (Expected from Sequence), Rat (Expected from Sequence)
Clonality
Polyclonal
Isotype
IgG
Specificity
This item recognises CD294, also known as chemoattractant receptor homologous molecule expressed on Th2 cells (CRTH2) and GRP44.
CD294 is a G protein-coupled receptor which has a high affinity for prostaglandin D2 (PGD2).
CD294 is predominantly expressed on Th2 cells, basophils and eosinophils, and its activation by PDG2 mediates chemotaxis of these cells to inflammatory sites. CD294 may be a useful marker for Th2 cells, and enhances their function and signalling with a possible role in Th2 cell differentiation.
PGD2 is thought to contribute to bronchoconstriction, eosinophilia and mucus production in allergic asthma, and CD294 may contribute to this disease.
CD294 is a G protein-coupled receptor which has a high affinity for prostaglandin D2 (PGD2).
CD294 is predominantly expressed on Th2 cells, basophils and eosinophils, and its activation by PDG2 mediates chemotaxis of these cells to inflammatory sites. CD294 may be a useful marker for Th2 cells, and enhances their function and signalling with a possible role in Th2 cell differentiation.
PGD2 is thought to contribute to bronchoconstriction, eosinophilia and mucus production in allergic asthma, and CD294 may contribute to this disease.
Form/Format
Purified
Purified IgG - liquid
Purified IgG - liquid
Concentration
IgG concentration 1.0mg/ml (varies by lot)
Sequence Length
382
Applicable Applications for anti-CD294 antibody
WB (Western Blot), IHC (Immunohistochemistry), ELISA
Perservative Stabilisers
0.02% Sodium Azide (NaN3)
Immunogen
A synthetic peptide corresponding to an 18 amino acid sequence from near the amino terminus of human CD294 - KLH conjugated.
Histology Positive Control Tissue
Histology Positive Control Tissue
Antiserum Preparation
Antisera to human CD294 were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG prepared from whole serum by affinity chromatography.
Target Species
Human
Preparation and Storage
Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 12 months from date of despatch.
Shelf Life: 12 months from date of despatch.
Application Data
(Western blotting of Jurkat cell lysate probed with Rabbit anti Human CD294 (AAA50092))
Application Data
(Western blotting of Jurkat cell lysate probed with Rabbit anti Human CD294 (AAA50092))
Application Data
(Staining of formalin fixed, paraffin embedded human cerebllum with Rabbit anti Human CD294 (AAA50092))
Application Data
(Staining of formalin fixed, paraffin embedded human cerebllum with Rabbit anti Human CD294 (AAA50092))
Application Data
(Staining of formalin fixed, paraffin embedded human adrenal gland with Rabbit anti Human CD294 (AAA50092))
Application Data
(Staining of formalin fixed, paraffin embedded human adrenal gland with Rabbit anti Human CD294 (AAA50092))
Application Data
(Staining of formalin fixed, paraffin embedded human brain cortex with Rabbit anti Human CD294 (AAA50092))
Application Data
(Staining of formalin fixed, paraffin embedded human brain cortex with Rabbit anti Human CD294 (AAA50092))
Related Product Information for anti-CD294 antibody
MBS224236 recognises CD294, also known as chemoattractant receptor homologous molecule expressed on Th2 cells (CRTH2) and GRP44. CD294 is a G protein-coupled receptor which has a high affinity for prostaglandin D2 (PGD2). CD294 is predominantly expressed on Th2 cells, basophils and eosinophils, and its activation by PDG2 mediates chemotaxis of these cells to inflammatory sites. CD294 may be a useful marker for Th2 cells, and enhances their function and signalling with a possible role in Th2 cell differentiation. PGD2 is thought to contribute to bronchoconstriction, eosinophilia and mucus production in allergic asthma, and CD294 may contribute to this disease.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
42,950 Da
NCBI Official Full Name
prostaglandin D2 receptor 2
NCBI Official Synonym Full Names
prostaglandin D2 receptor 2
NCBI Official Symbol
Ptgdr2
NCBI Official Synonym Symbols
Crth2; Gpr44; Grp45
NCBI Protein Information
prostaglandin D2 receptor 2; G protein-coupled receptor 44; G-protein coupled receptor 44; PGD2 receptor; chemoattractant receptor-homologous molecule expressed on TH2 cells; prostaglandin D2 receptor CRTH2
UniProt Protein Name
Prostaglandin D2 receptor 2
UniProt Gene Name
Ptgdr2
UniProt Synonym Gene Names
Crth2
UniProt Entry Name
PD2R2_MOUSE
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Product Notes
The CD294 ptgdr2 (Catalog #AAA50092) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The RABBIT ANTI HUMAN CD294 (N-TERMINAL) reacts with Mouse (Expected from Sequence), Rat (Expected from Sequence) and may cross-react with other species as described in the data sheet. AAA Biotech's CD294 can be used in a range of immunoassay formats including, but not limited to, WB (Western Blot), IHC (Immunohistochemistry), ELISA. Researchers should empirically determine the suitability of the CD294 ptgdr2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD294, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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