Application Data
(Anti-CIAS1/NALP3 Picoband antibody, AAA45725-2.jpgAll lanes: Anti CIAS1 (AAA45725) at 0.5ug/mlLane 1: HELA Whole Cell Lysate at 40ugLane 2: MCF-7 Whole Cell Lysate at 40ugLane 3: JURKAT Whole Cell Lysate at 40ugLane 4: HEPG2 Whole Cell Lysate at 40ugPredicted bind size: 118KDObserved bind size: 118KD)
Rabbit anti-Human CIAS1/NALP3 Polyclonal Antibody | anti-NLRP3 antibody
Anti-CIAS1/NALP3 Antibody
Gene Names
NLRP3; AII; AVP; FCU; MWS; FCAS; CIAS1; NALP3; C1orf7; CLR1.1; PYPAF1; AGTAVPRL
Reactivity
Human
Applications
Western Blot
Purity
Immunogen affinity purified.
Synonyms
CIAS1/NALP3, Antibody; Anti-CIAS1/NALP3 Antibody; NACHT, LRR and PYD domains-containing protein 3; NLR family, pyrin domain containing 3; AGTAVPRL antibody; AII/AVP antibody; Angiotensin/vasopressin receptor AII/AVP like antibody; Angiotensin/vasopressin receptor AII/AVP-like antibody; C1orf7 antibody; Caterpiller protein 1.1 antibody; CIAS 1 antibody; CIAS1 antibody; CLR1.1 antibody; Cold autoinflammatory syndrome 1 antibody; Cold autoinflammatory syndrome 1 protein antibody; Cryopyrin antibody; Familial cold autoinflammatory syndrome antibody; FCAS antibody; FCU antibody; LRR and PYD domains-containing protein 3 antibody; Muckle-Wells syndrome antibody; MWS antibody; NACHT antibody; NACHT LRR and PYD containing protein 3 antibody; NALP 3 antibody; NALP3 antibody; NALP3_HUMAN antibody; NLRP3 antibody; PYPAF 1 antibody; PYPAF1 antibody; PYRIN containing APAF1 like protein 1 antibody; PYRIN-containing APAF1-like protein 1 antibody; anti-NLRP3 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Immunogen affinity purified.
Form/Format
Lyophilized
Sequence Length
1036
Applicable Applications for anti-NLRP3 antibody
WB (Western Blot)
Immunogen
E Coli-derived human CIAS1 recombinant protein (Position: D21-K194). Human CIAS1 shares 77% amino acid (aa) sequence identity with mouse CIAS1.
Contents
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Preparation and Storage
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
Application Data
(Anti-CIAS1/NALP3 Picoband antibody, AAA45725-2.jpgAll lanes: Anti CIAS1 (AAA45725) at 0.5ug/mlLane 1: HELA Whole Cell Lysate at 40ugLane 2: MCF-7 Whole Cell Lysate at 40ugLane 3: JURKAT Whole Cell Lysate at 40ugLane 4: HEPG2 Whole Cell Lysate at 40ugPredicted bind size: 118KDObserved bind size: 118KD)
Application Data
(Anti-CIAS1/NALP3 Picoband antibody, AAA45725-2.jpgAll lanes: Anti CIAS1 (AAA45725) at 0.5ug/mlLane 1: HELA Whole Cell Lysate at 40ugLane 2: MCF-7 Whole Cell Lysate at 40ugLane 3: JURKAT Whole Cell Lysate at 40ugLane 4: HEPG2 Whole Cell Lysate at 40ugPredicted bind size: 118KDObserved bind size: 118KD)
Application Data
(Anti-CIAS1/NALP3 Picoband antibody, AAA45725-1.jpgAll lanes: Anti CIAS1 (AAA45725) at 0.5ug/mlWB: Recombinant Human CIAS1 Protein 0.5ngPredicted bind size: 37KDObserved bind size: 37KD)
Application Data
(Anti-CIAS1/NALP3 Picoband antibody, AAA45725-1.jpgAll lanes: Anti CIAS1 (AAA45725) at 0.5ug/mlWB: Recombinant Human CIAS1 Protein 0.5ngPredicted bind size: 37KDObserved bind size: 37KD)
Related Product Information for anti-NLRP3 antibody
Description: Rabbit IgG polyclonal antibody for NACHT, LRR and PYD domains-containing protein 3(NLRP3) detection. Tested with WB in Human.
Background: NLRP3(NLR FAMILY, PYRIN DOMAIN-CONTAINING 3),also known as CIAS1, CRYOPYRIN, NALP3 or PYPAF1, is a protein that in humans is encoded by the NLRP3 gene. It is mapped to 1q44. The encoded protein may play a role in the regulation of inflammation and apoptosis. Mutation of the NALP3 nucleotide-binding domain reduced ATP binding, CASP1 activation, IL1B production, cell death, macromolecular complex formation, self-association, and association with ASC. Consistent with an essential role for Nlrp3 inflammasomes in antifungal immunity, it has been showed that Nlrp3-deficient mice are hypersusceptible to C. albicans infection. Activation of the NLRP3 inflammasome in response to virus or to RNA was dependent upon lysosomal maturation and reactive oxygen species production in human cells. The NLRP3 inflammasome senses obesity-associated danger signals and contributes to obesity-induced inflammation and insulin resistance.
Background: NLRP3(NLR FAMILY, PYRIN DOMAIN-CONTAINING 3),also known as CIAS1, CRYOPYRIN, NALP3 or PYPAF1, is a protein that in humans is encoded by the NLRP3 gene. It is mapped to 1q44. The encoded protein may play a role in the regulation of inflammation and apoptosis. Mutation of the NALP3 nucleotide-binding domain reduced ATP binding, CASP1 activation, IL1B production, cell death, macromolecular complex formation, self-association, and association with ASC. Consistent with an essential role for Nlrp3 inflammasomes in antifungal immunity, it has been showed that Nlrp3-deficient mice are hypersusceptible to C. albicans infection. Activation of the NLRP3 inflammasome in response to virus or to RNA was dependent upon lysosomal maturation and reactive oxygen species production in human cells. The NLRP3 inflammasome senses obesity-associated danger signals and contributes to obesity-induced inflammation and insulin resistance.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
UniProt Accession #
Molecular Weight
115,968 Da
NCBI Official Full Name
NACHT, LRR and PYD domains-containing protein 3
NCBI Official Synonym Full Names
NLR family, pyrin domain containing 3
NCBI Official Symbol
NLRP3
NCBI Official Synonym Symbols
AII; AVP; FCU; MWS; FCAS; CIAS1; NALP3; C1orf7; CLR1.1; PYPAF1; AGTAVPRL
NCBI Protein Information
NACHT, LRR and PYD domains-containing protein 3; cryopyrin; caterpiller protein 1.1; PYRIN-containing APAF1-like protein 1; NACHT, LRR and PYD containing protein 3; cold autoinflammatory syndrome 1 protein; NACHT domain-, leucine-rich repeat-, and PYD-containing protein 3; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 3
UniProt Protein Name
NACHT, LRR and PYD domains-containing protein 3
UniProt Gene Name
NLRP3
UniProt Synonym Gene Names
C1orf7; CIAS1; NALP3; PYPAF1; CLR1.1
UniProt Entry Name
NALP3_HUMAN
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Product Notes
The NLRP3 nlrp3 (Catalog #AAA45725) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-CIAS1/NALP3 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CIAS1/NALP3 can be used in a range of immunoassay formats including, but not limited to, WB (Western Blot). Researchers should empirically determine the suitability of the NLRP3 nlrp3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CIAS1/NALP3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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