IHC (Immunohiostchemistry)
(COL18A1 Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human hepatocarcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the COL18A1 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)
Rabbit anti-Human, mouse COL18A1 Polyclonal Antibody | anti-COL18A1 antibody
COL18A1 Antibody (Center)
Gene Names
COL18A1; KS; KNO; KNO1
Reactivity
Human, mouse
Applications
Immunohistochemistry, ELISA, Western Blot
Purity
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Synonyms
COL18A1, Antibody; COL18A1 Antibody (Center); Collagen alpha-1(XVIII) chain; Endostatin; COL18A1; anti-COL18A1 antibody
Host
Rabbit
Reactivity
Human, mouse
Clonality
Polyclonal
Isotype
Rabbit Ig
Specificity
This COL18A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1311-1339 amino acids from the Central region of human COL18A1.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.5 (varies by lot)
Sequence Positions
1311-1339
Sequence Length
1516
Applicable Applications for anti-COL18A1 antibody
IHC (Immunohistochemistry), ELISA, WB (Western Blot)
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
IHC (Immunohiostchemistry)
(COL18A1 Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human hepatocarcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the COL18A1 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)
IHC (Immunohiostchemistry)
(COL18A1 Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human hepatocarcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the COL18A1 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)
WB (Western Blot)
(COL18A1 Antibody (Center) western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the COL18A1 antibody detected the COL18A1 protein (arrow).)
WB (Western Blot)
(COL18A1 Antibody (Center) western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the COL18A1 antibody detected the COL18A1 protein (arrow).)
Related Product Information for anti-COL18A1 antibody
COL18A1 is the alpha chain of type XVIII collagen.
This collagen is one of the multiplexins, extracellular matrix
proteins that contain multiple triple-helix domains (collagenous
domains) interrupted by non-collagenous domains. The
proteolytically produced C-terminal fragment of type XVIII collagen
is endostatin, a potent antiangiogenic protein. Mutations in this
gene are associated with Knobloch syndrome. The main features of
this syndrome involve retinal abnormalities, so type XVIII collagen
may play an important role in retinal structure and in neural tube
closure.
This collagen is one of the multiplexins, extracellular matrix
proteins that contain multiple triple-helix domains (collagenous
domains) interrupted by non-collagenous domains. The
proteolytically produced C-terminal fragment of type XVIII collagen
is endostatin, a potent antiangiogenic protein. Mutations in this
gene are associated with Knobloch syndrome. The main features of
this syndrome involve retinal abnormalities, so type XVIII collagen
may play an important role in retinal structure and in neural tube
closure.
Product Categories/Family for anti-COL18A1 antibody
References
Hamano, Y., et al. J. Am. Soc. Nephrol. 21(9):1445-1455(2010)
Roberts, K.E., et al. Gastroenterology 139(1):130-139(2010)
Lee, K.S., et al. Tumour Biol. 31(3):165-170(2010)
Faye, C., et al. Biochem. J. 427(3):467-475(2010)
Polikarpova, S.B., et al. Bull. Exp. Biol. Med. 148(4):634-637(2009)
Roberts, K.E., et al. Gastroenterology 139(1):130-139(2010)
Lee, K.S., et al. Tumour Biol. 31(3):165-170(2010)
Faye, C., et al. Biochem. J. 427(3):467-475(2010)
Polikarpova, S.B., et al. Bull. Exp. Biol. Med. 148(4):634-637(2009)
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
178188
NCBI Official Full Name
collagen alpha-1(XVIII) chain isoform 1 preproprotein
NCBI Official Synonym Full Names
collagen, type XVIII, alpha 1
NCBI Official Symbol
COL18A1
NCBI Official Synonym Symbols
KS; KNO; KNO1
NCBI Protein Information
collagen alpha-1(XVIII) chain
UniProt Protein Name
Collagen alpha-1(XVIII) chain
UniProt Gene Name
COL18A1
UniProt Entry Name
COIA1_HUMAN
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Product Notes
The COL18A1 col18a1 (Catalog #AAA285711) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1311-1339. The COL18A1 Antibody (Center) reacts with Human, mouse and may cross-react with other species as described in the data sheet. AAA Biotech's COL18A1 can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), ELISA, WB (Western Blot). Researchers should empirically determine the suitability of the COL18A1 col18a1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "COL18A1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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