WB (Western Blot)
(Western Blot of CXCR2-201AP and PC-CXCR2.Antibody dilution 1:500 in DiluObuffer)
Rabbit CXCR2 Polyclonal Antibody | anti-CXCR2 antibody
CXCR2 Antibody
Gene Names
CXCR2; CD182; IL8R2; IL8RA; IL8RB; CMKAR2; CDw128b
Reactivity
Human, Mouse, Rat
Applications
Western Blot, Flow Cytometry, Functional Assay, Immunoprecipitation, Immunohistochemistry, Immunofluorescence, Immunocytochemistry, ELISA
Synonyms
CXCR2, Antibody; CXCR2 Antibody; C-X-C chemokine receptor type 2 antibody; CD 182 antibody; CD182 antigen antibody; CDw128b antibody; Chemokine (CXC) receptor 2 antibody; CMKAR2 antibody; CXCR2 antibody; GRO/MGSA receptor antibody; High affinity interleukin-8 receptor B antibody; IL8R B antibody; IL8R2 antibody; IL8RA antibody; Interleukin 8 receptor, beta antibody; Interleukin 8 receptor, type 2 antibody; anti-CXCR2 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Form/Format
Affinity Purified Immunoglobulins
Concentration
~0.50 ug/ul in antibody stabilization buffer (varies by lot)
Sequence Length
360
Applicable Applications for anti-CXCR2 antibody
WB (Western Blot), FCM/FACS (Flow Cytometry), IP (Immunoprecipitation), IHC (Immunohistochemistry), IF (Immunofluorescence), ICC (Immunocytochemistry), ELISA, CM (Confocal Microscopy)
Immunogen
Corresponding to amino acids 18-39 of Human CXCR2
Sequence: EDLSNYSYSSTLPPFLLDAAPC
Sequence: EDLSNYSYSSTLPPFLLDAAPC
Expression
Up-regulated by CREB3
Determinant
N-epitope
Molecular Function
G-Protein coupled receptor, Transducer, chemokine receptor activity
Structure
Binds to HIV-1 Tat and interacts with ARRB1
Subcellular Location
Cell membrane; Multi-pass membrane protein
Preparation and Storage
-20°C for long term storage
WB (Western Blot)
(Western Blot of CXCR2-201AP and PC-CXCR2.Antibody dilution 1:500 in DiluObuffer)
WB (Western Blot)
(Western Blot of CXCR2-201AP and PC-CXCR2.Antibody dilution 1:500 in DiluObuffer)
Related Product Information for anti-CXCR2 antibody
Receptor for interleukin-8, binding of IL-8 to the receptor causes the activation of neutrophils. This response is mediated by a G-protein which activates a phosphatidyinositol-calcium second messenger system.
Overview: Chemokine (Chemoattractant Cytokines) are small peptides that are potent activators and chemo-attractants for leukocyte subpopulations and other non-hemopoietic cells. Chemokine receptors (CXCR) belong to the super-family of G protein-coupled receptors (GPCR), which regulate the trafficking and activation of leukocytes, and operate as co-receptors in the entry of HIV-1 and proliferation and migration of immature neurons, glia and their precursors (1). Furthermore, chemokine receptors participate in the etiology and progression of various brain disorders, including AIDS dementia, neuro-inflammatory disease and neuroplasia, making them important potential therapeutic targets in these cases. Activation of naïve T cells by specific antigen and cytokines, up-regulate cell adhesion molecules (CAM) as well as chemokine receptors on their surface, which directs them to migrate towards the inflamed tissues. The CXCR receptor protein is approximately 45-55 kDa (405 amino acids) protein which has 7 transmembrane domains, characteristic of G-protein coupled receptors. The protein has putative N-glycosylation sites near the extracellular N-terminal end of the protein. The protein has a large 3rd intracellular loop which interacts with G-proteins. The short carboxy terminal is intracellular and has putative post-translational sites. The Anti-CXCR2-selective antibodies were generated against unique peptide sequence from CXCR2 receptors gene that is expressed only in a CXCR2 receptor subtype. The polyclonal antibodies were affinity purified on an immobilized antigen based affinity chromatography.
Overview: Chemokine (Chemoattractant Cytokines) are small peptides that are potent activators and chemo-attractants for leukocyte subpopulations and other non-hemopoietic cells. Chemokine receptors (CXCR) belong to the super-family of G protein-coupled receptors (GPCR), which regulate the trafficking and activation of leukocytes, and operate as co-receptors in the entry of HIV-1 and proliferation and migration of immature neurons, glia and their precursors (1). Furthermore, chemokine receptors participate in the etiology and progression of various brain disorders, including AIDS dementia, neuro-inflammatory disease and neuroplasia, making them important potential therapeutic targets in these cases. Activation of naïve T cells by specific antigen and cytokines, up-regulate cell adhesion molecules (CAM) as well as chemokine receptors on their surface, which directs them to migrate towards the inflamed tissues. The CXCR receptor protein is approximately 45-55 kDa (405 amino acids) protein which has 7 transmembrane domains, characteristic of G-protein coupled receptors. The protein has putative N-glycosylation sites near the extracellular N-terminal end of the protein. The protein has a large 3rd intracellular loop which interacts with G-proteins. The short carboxy terminal is intracellular and has putative post-translational sites. The Anti-CXCR2-selective antibodies were generated against unique peptide sequence from CXCR2 receptors gene that is expressed only in a CXCR2 receptor subtype. The polyclonal antibodies were affinity purified on an immobilized antigen based affinity chromatography.
Product Categories/Family for anti-CXCR2 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
Predicted: 55 kDa
NCBI Official Full Name
C-X-C chemokine receptor type 2
NCBI Official Synonym Full Names
C-X-C motif chemokine receptor 2
NCBI Official Symbol
CXCR2
NCBI Official Synonym Symbols
CD182; IL8R2; IL8RA; IL8RB; CMKAR2; CDw128b
NCBI Protein Information
C-X-C chemokine receptor type 2
UniProt Protein Name
C-X-C chemokine receptor type 2
UniProt Gene Name
CXCR2
UniProt Synonym Gene Names
IL8RB; CXC-R2; CXCR-2; IL-8R B
UniProt Entry Name
CXCR2_HUMAN
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Product Notes
The CXCR2 cxcr2 (Catalog #AAA75854) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CXCR2 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's CXCR2 can be used in a range of immunoassay formats including, but not limited to, WB (Western Blot), FCM/FACS (Flow Cytometry), IP (Immunoprecipitation), IHC (Immunohistochemistry), IF (Immunofluorescence), ICC (Immunocytochemistry), ELISA, CM (Confocal Microscopy). Researchers should empirically determine the suitability of the CXCR2 cxcr2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CXCR2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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