IHC (Immunohistochemisry)
(Immunohistochemistry of paraffin-embedded human colon cancer using AAA119063 at dilution 1:100)
Rabbit anti-Human, Rat DHX58 Polyclonal Antibody | anti-DHX58 antibody
DHX58 Antibody
Gene Names
DHX58; LGP2; RLR-3; D11LGP2; D11lgp2e
Reactivity
Human, Rat
Applications
Immunohistochemistry, Western Blot, ELISA
Purity
Antigen Affinity Purified
Synonyms
DHX58, Antibody; DHX58 Antibody; Probable ATP-dependent helicase LGP2; Protein D11Lgp2 homolog; RIG-I-like receptor 3; RLR-3; RIG-I-like receptor LGP2; RLR; DHX58; D11LGP2E; LGP2; anti-DHX58 antibody
Host
Rabbit
Reactivity
Human, Rat
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Antigen Affinity Purified
Sequence Length
678
Applicable Applications for anti-DHX58 antibody
IHC (Immunohistochemistry), WB (Western Blot), ELISA
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Conjugate
Non-conjugated
Immunogen
Recombinant human Probable ATP-dependent RNA helicase DHX58 protein (389-678aa)
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-164861
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
IHC (Immunohistochemisry)
(Immunohistochemistry of paraffin-embedded human colon cancer using AAA119063 at dilution 1:100)
IHC (Immunohistochemisry)
(Immunohistochemistry of paraffin-embedded human colon cancer using AAA119063 at dilution 1:100)
IHC (Immunohiostchemistry)
(Immunohistochemistry of paraffin-embedded human breast cancer using AAA119063 at dilution 1:100)
IHC (Immunohiostchemistry)
(Immunohistochemistry of paraffin-embedded human breast cancer using AAA119063 at dilution 1:100)
WB (Western Blot)
(Western blotAll lanes: DHX58 antibody at 12ug/mlLane 1:293T whole cell lysateLane 2:Rat kidney tissueSecondaryGoat polyclonal to rabbit at 1/10000 dilutionPredicted band size: 77kDaObserved band size: 77kDa)
WB (Western Blot)
(Western blotAll lanes: DHX58 antibody at 12ug/mlLane 1:293T whole cell lysateLane 2:Rat kidney tissueSecondaryGoat polyclonal to rabbit at 1/10000 dilutionPredicted band size: 77kDaObserved band size: 77kDa)
Related Product Information for anti-DHX58 antibody
Acts as a regulator of DDX58/RIG-I and IFIH1/MDA5 mediated antiviral signaling. Cannot initiate antiviral signaling as it lacks the CARD domain required for activating MAVS/IPS1-dependent signaling events. Can have both negative and positive regulatory functions related to DDX58/RIG-I and IFIH1/MDA5 signaling and this role in regulating signaling may be complex and could probably depend on characteristics of the infecting virus or target cells, or both. Its inhibitory action on DDX58/RIG-I signaling may involve the following mechanisms: competition with DDX58/RIG-I for binding to the viral RNA, binding to DDX58/RIG-I and inhibiting its dimerization and interaction with MAVS/IPS1, competing with IKBKE in its binding to MAVS/IPS1 thereby inhibiting activation of interferon regulatory factor 3 (IRF3). Its positive regulatory role may involve unwinding or stripping nucleoproteins of viral RNA thereby facilitating their recognition by DDX58/RIG-I and IFIH1/MDA5. Involved in the innate immune response to various RNA viruses and some DNA viruses such as poxviruses, and also to the bacterial pathogen Listeria monocytogenes. Can bind both ssRNA and dsRNA, with a higher affinity for dsRNA. Shows a preference to 5'-triphosphorylated RNA, although it can recognize RNA lacking a 5'-triphosphate.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
76,613 Da
NCBI Official Full Name
probable ATP-dependent RNA helicase DHX58
NCBI Official Synonym Full Names
DEXH-box helicase 58
NCBI Official Symbol
DHX58
NCBI Official Synonym Symbols
LGP2; RLR-3; D11LGP2; D11lgp2e
NCBI Protein Information
probable ATP-dependent RNA helicase DHX58
UniProt Protein Name
Probable ATP-dependent RNA helicase DHX58
UniProt Gene Name
DHX58
UniProt Synonym Gene Names
D11LGP2E; LGP2; RLR-3; RLR
UniProt Entry Name
DHX58_HUMAN
Similar Products
Product Notes
The DHX58 dhx58 (Catalog #AAA119063) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The DHX58 Antibody reacts with Human, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's DHX58 can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), WB (Western Blot), ELISA. Researchers should empirically determine the suitability of the DHX58 dhx58 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "DHX58, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.