Rabbit ERLIN1/2 Polyclonal Antibody | anti-ERLIN1/2 antibody

ERLIN1/2 Polyclonal Antibody

Cat. Num. AAA173834

• Gene Names: ERLIN1; KE04; KEO4; SPFH1; SPG62; Erlin-1; C10orf69
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Immunohistochemistry, Western Blot
• Purity: Affinity Purification
• Synonyms: ERLIN1/2, Antibody; ERLIN1/2 Polyclonal Antibody; anti-ERLIN1/2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity Purification
• Concentration: 1mg/mL (varies by lot)
• Sequence Length: 348

• Applicable Applications for anti-ERLIN1/2 antibody: ELISA, IHC (Immunohistochemistry), WB (Western Blot)
• Immunogen: Synthesized peptide derived from ERLIN1/2
• Buffer: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol pH 7.4.
• Preparation and Storage: Store at -20 degree C. Avoid freeze / thaw cycles.

IHC (Immunohistochemisry)

(Immunohistochemistry of paraffin-embedded Human liver tissue using ERLIN1/2 Polyclonal Antibody at dilution of 1:200.)

WB (Western Blot)

(Western Blot analysis of various cells using ERLIN1/2 Polyclonal Antibody at dilution of 1:1000.)

WB (Western Blot)

(Western Blot analysis of HepG2, 3T3, Hela cells using ERLIN1/2 Polyclonal Antibody at dilution of 1:800.)

Related Product Information for anti-ERLIN1/2 antibody

ERLIN1 (ER Lipid Raft Associated 1) is a Protein Coding gene. Diseases associated with ERLIN1 include Hereditary Spastic Paraplegia 62 and Spastic Paraplegia 62. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and CDK-mediated phosphorylation and removal of Cdc6. An important paralog of this gene is ERLIN2.The protein encoded by this gene is part of a protein complex that mediates degradation of inositol 1, 4, 5-trisphosphate receptors in the endoplasmic reticulum. The encoded protein also binds cholesterol and regulates the SREBP signaling pathway, which promotes cellular cholesterol homeostasis. Defects in this gene have been associated with spastic paraplegia 62. ERLIN2 (ER Lipid Raft Associated 2) is a Protein Coding gene. Diseases associated with ERLIN2 include Spastic Paraplegia 18, Autosomal Recessive and Recessive Intellectual Disability-Motor Dysfunction-Multiple Joint Contractures Syndrome. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and FGFR1 mutant receptor activation. An important paralog of this gene is ERLIN1.This gene encodes a member of the SPFH domain-containing family of lipid raft-associated proteins. The encoded protein is localized to lipid rafts of the endoplasmic reticulum and plays a critical role in inositol 1, 4, 5-trisphosphate (IP3) signaling by mediating ER-associated degradation of activated IP3 receptors. Mutations in this gene are a cause of spastic paraplegia-18 (SPG18). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

NCBI and Uniprot Product Information

• NCBI GI #: 154800489
• NCBI GeneID: 10613
• NCBI Accession #: NP_001094096.1
• NCBI GenBank Nucleotide #: NM_001100626.1
• UniProt Accession #: O75477; Q53HV0; B0QZ42
• Molecular Weight: 40+42kDa
• NCBI Official Full Name: erlin-1 isoform a
• NCBI Official Synonym Full Names: ER lipid raft associated 1
• NCBI Official Symbol: ERLIN1
• NCBI Official Synonym Symbols: KE04; KEO4; SPFH1; SPG62; Erlin-1; C10orf69
• NCBI Protein Information: erlin-1
• UniProt Protein Name: Erlin-1
• UniProt Gene Name: ERLIN1
• UniProt Synonym Gene Names: C10orf69; KE04; KEO4; SPFH1; SPFH domain-containing protein 1