Rabbit anti-Human Factor XIII B Polyclonal Antibody | anti-F13B antibody

Factor XIII B Polyclonal Antibody

Cat. Num. AAA173805

• Gene Names: F13B; FXIIIB
• Reactivity: Human
• Applications: ELISA, Immunohistochemistry, Western Blot
• Purity: Affinity Purification
• Synonyms: Factor XIII B, Antibody; Factor XIII B Polyclonal Antibody; Coagulation factor XIII B chain; Fibrin-stabilizing factor B subunit; Protein-glutamine gamma-glutamyltransferase B chain; Transglutaminase B chain; anti-F13B antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity Purification
• Concentration: 1mg/mL (varies by lot)
• Sequence Length: 661

• Applicable Applications for anti-F13B antibody: ELISA, IHC (Immunohistochemistry), WB (Western Blot)
• Immunogen: Synthesized peptide derived from the Internal region of human Factor XIII B.
• Buffer: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol pH 7.4.
• Preparation and Storage: Store at -20 degree C. Avoid freeze / thaw cycles.

IHC (Immunohiostchemistry)

(Immunohistochemistry of paraffin-embedded Human liver tissue using Factor XIII B Polyclonal Antibody at dilution of 1:200.)

WB (Western Blot)

(Western Blot analysis of various cells using Factor XIII B Polyclonal Antibody at dilution of 1:2000.)

Related Product Information for anti-F13B antibody

This gene encodes coagulation factor XIII B subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as a plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon activation by the cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion.

NCBI and Uniprot Product Information

• NCBI GI #: 110611237
• NCBI GeneID: 2165
• NCBI Accession #: NP_001985.2
• NCBI GenBank Nucleotide #: NM_001994.2
• UniProt Accession #: P05160; Q5VYL5; A8K3E5
• Molecular Weight: Calculated Molecular Weight: 76kDa; Observed Molecular Weight: 65kDa
• NCBI Official Full Name: coagulation factor XIII B chain
• NCBI Official Synonym Full Names: coagulation factor XIII B chain
• NCBI Official Symbol: F13B
• NCBI Official Synonym Symbols: FXIIIB
• NCBI Protein Information: coagulation factor XIII B chain
• UniProt Protein Name: Coagulation factor XIII B chain
• UniProt Gene Name: F13B