IHC (Immunohistochemisry)
(FOS/c-FOS Antibody-Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE))
Goat FOS/c-FOS Polyclonal Antibody | anti-FOS antibody
FOS/c-FOS Goat anti-Human Polyclonal (aa283-295) Antibody
Gene Names
FOS; p55; AP-1; C-FOS
Reactivity
Dog, Guinea pig, Sheep, Bovine, Pig, Horse, Human, Monkey
Applications
Western Blot, ELISA, Immunohistochemistry, Immunohistochemistry
Purity
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Synonyms
FOS/c-FOS, Antibody; FOS/c-FOS Goat anti-Human Polyclonal (aa283-295) Antibody; PathPlus FOS/c-FOS Antibody (aa283-295); FOS; Activator protein 1; AP-1; Cellular oncogene c-fos; Cellular oncogene fos; Proto-oncogene c-Fos; v-fos; C-FOS; G0s7; p55; anti-FOS antibody
Host
Goat
Reactivity
Dog, Guinea pig, Sheep, Bovine, Pig, Horse, Human, Monkey
Clonality
Polyclonal
Specificity
Human FOS/c-FOS
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Form/Format
TBS, pH7.3, 0.02% Sodium Azide, 0.5% BSA
Concentration
0.5mg/ml (varies by lot)
Applicable Applications for anti-FOS antibody
WB (Western Blot), ELISA (Peptide ELISA), IHC (Immunohistochemistry), IHC (Immunohistochemistry)
Target
Human FOS/c-FOS
Immunogen
Peptide with sequence C-SETARSVPDMDLS, from the internal region of the protein sequence according to NP_005243.1.
Conjugation
Unconjugated
Epitope
aa283-295
Preparation and Storage
Aliquot and store at -20 degree C. Avoid freeze-thaw cycles.
IHC (Immunohistochemisry)
(FOS/c-FOS Antibody-Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohistochemisry)
(FOS/c-FOS Antibody-Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE))
WB (Western Blot)
(FOS/c-FOS Antibody-FOS antibody (0.3 ug/ml) staining of HeLa lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.)
WB (Western Blot)
(FOS/c-FOS Antibody-FOS antibody (0.3 ug/ml) staining of HeLa lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.)
WB (Western Blot)
(FOS/c-FOS Antibody-c-FOS antibody (0.3ug/ml) staining of HeLa lysate (35ug protein in RIPA buffer). Detected by chemiluminescence.)
WB (Western Blot)
(FOS/c-FOS Antibody-c-FOS antibody (0.3ug/ml) staining of HeLa lysate (35ug protein in RIPA buffer). Detected by chemiluminescence.)
Related Product Information for anti-FOS antibody
C-FOS antibody is an unconjugated goat polyclonal antibody to c-FOS (FOS)(aa283-295) from human. It is reactive with human, bovine, dog and other species. Validated for IHC, Peptide-ELISA and WB.
FOS (c-Fos, FBJ murine osteosarcoma viral oncogene homolog) is a component of the DNA-binding AP-1 complex together with c-Jun that regulates gene expression and is upregulated in numerous cancers including osteocarcinoma, endometrial cancer, and breast cancer. FOS is involved in the proliferation, differentiation, survival, and angiogenesis of cells, and deregulation of FOS can induce invasion and metastasis via destabilization of these various processes. Separately, FOS is used as a marker of neuronal activity, due to FOS being upregulated after neurons fire action potentials. Its activity is relevant to drug addiction research, as it is upregulated in the prefrontal cortex and nucleus accumbens following use of methamphetamines and psychoactive drugs. In immunohistochemistry, FOS has positive nuclear and cytoplasmic staining in most tissues throughout the body.
FOS (c-Fos, FBJ murine osteosarcoma viral oncogene homolog) is a component of the DNA-binding AP-1 complex together with c-Jun that regulates gene expression and is upregulated in numerous cancers including osteocarcinoma, endometrial cancer, and breast cancer. FOS is involved in the proliferation, differentiation, survival, and angiogenesis of cells, and deregulation of FOS can induce invasion and metastasis via destabilization of these various processes. Separately, FOS is used as a marker of neuronal activity, due to FOS being upregulated after neurons fire action potentials. Its activity is relevant to drug addiction research, as it is upregulated in the prefrontal cortex and nucleus accumbens following use of methamphetamines and psychoactive drugs. In immunohistochemistry, FOS has positive nuclear and cytoplasmic staining in most tissues throughout the body.
References
Histol. Histopathol. 15 (3): 921 -8. PMID 10963134; Br. J. Cancer. 99 (8): 1269 -75, PMID: 18854825; Proc. Natl. Acad. Sci. U.S.A. 87 (17): 6912 -6, PMID: 2118661; Biol. Psychiatry. 53 (4): 275 -83, PMID: 12586446; Journal of Neuroscience Methods. 29 (3): 261 -265, PMID: 2507830;
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
40,695 Da
NCBI Official Full Name
proto-oncogene c-Fos
NCBI Official Synonym Full Names
FBJ murine osteosarcoma viral oncogene homolog
NCBI Official Symbol
FOS
NCBI Official Synonym Symbols
p55; AP-1; C-FOS
NCBI Protein Information
proto-oncogene c-Fos; activator protein 1; cellular oncogene c-fos; G0/G1 switch regulatory protein 7; FBJ murine osteosarcoma viral (v-fos) oncogene homolog (oncogene FOS)
UniProt Protein Name
Proto-oncogene c-Fos
UniProt Gene Name
FOS
UniProt Synonym Gene Names
G0S7
UniProt Entry Name
FOS_HUMAN
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Product Notes
The FOS fos (Catalog #AAA162723) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase. The FOS/c-FOS Goat anti-Human Polyclonal (aa283-295) Antibody reacts with Dog, Guinea pig, Sheep, Bovine, Pig, Horse, Human, Monkey and may cross-react with other species as described in the data sheet. AAA Biotech's FOS/c-FOS can be used in a range of immunoassay formats including, but not limited to, WB (Western Blot), ELISA (Peptide ELISA), IHC (Immunohistochemistry), IHC (Immunohistochemistry). Researchers should empirically determine the suitability of the FOS fos for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "FOS/c-FOS, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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