Rabbit GPCR MRGX2 Polyclonal Antibody | anti-GPCR antibody

GPCR MRGX2 Polyclonal Antibody

Cat. Num. AAA291620

• Gene Names: MRGPRX2; MGRG3; MRGX2
• Applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunohistochemistry
• Purity: Purified Rabbit Polyclonal Antibody (Pab)
• Synonyms: GPCR MRGX2, Antibody; GPCR MRGX2 Polyclonal Antibody; Mas-related G-protein coupled receptor member X2; MRGPRX2; MRGX2; Mas-related G-protein coupled receptor member X2, MRGPRX2, MRGX2; anti-GPCR antibody

• Host: Rabbit
• Clonality: Polyclonal
• Purity/Purification: Purified Rabbit Polyclonal Antibody (Pab)
• Form/Format: 0.01M TBS(pH7.4), 0.09% (W/V) sodium azide and 50% Glyce

• Applicable Applications for anti-GPCR antibody: ICC (Immunocytochemistry), IF (Immunofluorescence), IHC (Immunohistochemistry), IHC (Immunohistochemistry)
• Function: Mast cell-specific receptor for basic secretagogues, i.e. cationic amphiphilic drugs, as well as endo-or exogenous peptides, consisting of a basic head group and a hydrophobic core (PubMed:25517090). Recognizes and binds small molecules containing a cyclized tetrahydroisoquinoline (THIQ), such as non-steroidal neuromuscular blocking drugs (NMBDs), including tubocurarine and atracurium. In response to these compounds, mediates pseudo-allergic reactions characterized by histamine release, inflammation and airway contraction (By similarity). Acts as a receptor for a number of other ligands, including peptides and alkaloids, such as cortistatin-14, proadrenomedullin N-terminal peptides PAMP-12 and, at lower extent, PAMP-20, antibacterial protein LL-37, PMX-53 peptide, beta-defensins, and complanadine A.
• Cellular location: Cell membrane; Multi-pass membrane protein
• Tissue location: Mainly expressed in mast cells. Has a limited expression profile, both peripheral and within the central nervous system, with highest levels in dorsal root ganglion (PubMed:12915402) Detected in blood vessels, scattered lymphocytes, and gastrointestinal ganglia (at protein level) (PubMed:16161007).
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 2 weeks. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

NCBI and Uniprot Product Information

• NCBI GI #: 16876451
• NCBI GeneID: 117194
• NCBI Accession #: NP_473371.1
• NCBI GenBank Nucleotide #: NM_054030.2
• UniProt Accession #: Q96LB1; Q4QXW4; Q4QXW7; Q4QXX0; Q4QXX2; Q4QXX3; Q4QXX4; Q4QXX6; Q4QXX7; B5B0C7
• Molecular Weight: Calculated MW: 37,099 Da
• NCBI Official Full Name: mas-related G-protein coupled receptor member X2
• NCBI Official Synonym Full Names: MAS-related GPR, member X2
• NCBI Official Symbol: MRGPRX2
• NCBI Official Synonym Symbols: MGRG3; MRGX2
• NCBI Protein Information: mas-related G-protein coupled receptor member X2; G protein-coupled receptor MRGX2; Mas-related G protein-coupled receptor G3
• UniProt Protein Name: Mas-related G-protein coupled receptor member X2
• UniProt Gene Name: MRGPRX2
• UniProt Synonym Gene Names: MRGX2
• UniProt Entry Name: MRGX2_HUMAN