Rabbit GRF-1 Polyclonal Antibody | anti-GRF-1 antibody

GRF-1 (phospho Tyr1105) Polyclonal Antibody

Cat. Num. AAA294046

• Gene Names: ARHGAP35; GRF-1; GRLF1; P190A; P190-A; p190RhoGAP; p190ARhoGAP
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry, Western Blot
• Synonyms: GRF-1, Antibody; GRF-1 (phospho Tyr1105) Polyclonal Antibody; ARHGAP35; GRF1; GRLF1; KIAA1722; Rho GTPase-activating protein 35; Glucocorticoid receptor DNA-binding factor 1; Glucocorticoid receptor repression factor 1; GRF-1; Rho GAP p190A; p190-A; anti-GRF-1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal

• Applicable Applications for anti-GRF-1 antibody: IHC (Immunohistochemistry), WB (Western Blot)
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 2 weeks. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

IHC (Immunohiostchemistry)

(Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.)

WB (Western Blot)

(Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.)

Related Product Information for anti-GRF-1 antibody

Rho GTPase-activating protein (GAP)(PubMed:28894085). Binds several acidic phospholipids which inhibits the Rho GAP activity to promote the Rac GAP activity (PubMed:19673492). This binding is inhibited by phosphorylation by PRKCA (PubMed:19673492). Involved in cell differentiation as well as cell adhesion and migration, plays an important role in retinal tissue morphogenesis, neural tube fusion, midline fusion of the cerebral hemispheres and mammary gland branching morphogenesis (By similarity). Transduces signals from p21-ras to the nucleus, acting via the ras GTPase-activating protein (GAP)(By similarity). Transduces SRC-dependent signals from cell-surface adhesion molecules, such as laminin, to promote neurite outgrowth. Regulates axon outgrowth, guidance and fasciculation (By similarity). Modulates Rho GTPase-dependent F-actin polymerization, organization and assembly, is involved in polarized cell migration and in the positive regulation of ciliogenesis and cilia elongation (By similarity). During mammary gland development, is required in both the epithelial and stromal compartments for ductal outgrowth (By similarity). Represses transcription of the glucocorticoid receptor by binding to the cis-acting regulatory sequence 5'-GAGAAAAGAAACTGGAGAAACTC-3'; this function is however unclear and would need additional experimental evidences (PubMed:1894621).

NCBI and Uniprot Product Information

• NCBI GI #: 150417981
• NCBI GeneID: 2909
• NCBI Accession #: NP_004482.4
• NCBI GenBank Nucleotide #: NM_004491.4
• UniProt Accession #: Q9NRY4; Q14452; Q9C0E1; A7E2A4
• Molecular Weight: 170,514 Da
• NCBI Official Full Name: rho GTPase-activating protein 35
• NCBI Official Synonym Full Names: Rho GTPase activating protein 35
• NCBI Official Symbol: ARHGAP35
• NCBI Official Synonym Symbols: GRF-1; GRLF1; P190A; P190-A; p190RhoGAP; p190ARhoGAP
• NCBI Protein Information: rho GTPase-activating protein 35; rho GAP p190A; glucocorticoid receptor repression factor 1; glucocorticoid receptor DNA binding factor 1; glucocorticoid receptor DNA-binding factor 1
• UniProt Protein Name: Rho GTPase-activating protein 35
• UniProt Gene Name: ARHGAP35
• UniProt Synonym Gene Names: GRF1; GRLF1; KIAA1722; GRF-1; p190-A
• UniProt Entry Name: RHG35_HUMAN