Rabbit IGF1 Receptor Polyclonal Antibody | anti-IGF1R antibody

Polyclonal Anti-IGF1 Receptor antibody

Cat. Num. AAA44925

• Gene Names: IGF1R; IGFR; CD221; IGFIR; JTK13
• Reactivity: Reacts with: Human, Rat; Predicted to work with: Mouse
• Applications: Immunohistochemistry, Western Blot
• Purity: Immunogen affinity purified.
• Synonyms: IGF1 Receptor, Antibody; Polyclonal Anti-IGF1 Receptor antibody; Insulin-like growth factor 1 receptor; insulin-like growth factor 1 receptor; CD221 antibody; CD221 antigen antibody; IGF 1 receptor antibody; IGF 1R antibody; IGF I receptor antibody; IGF-I receptor antibody; IGF1R antibody; IGF1R_HUMAN antibody; IGFIR antibody; IGFIRC antibody; IGFR antibody; Insulin like growth factor 1 receptor antibody; Insulin like growth factor 1 receptor precursor antibody; Insulin-like growth factor 1 receptor beta chain antibody; Insulin-like growth factor I receptor antibody; JTK13 antibody; MGC142170 antibody; MGC142172 antibody; MGC18216 antibody; anti-IGF1R antibody

• Host: Rabbit
• Reactivity: Reacts with: Human, Rat; Predicted to work with: Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: No cross reactivity with other proteins
• Purity/Purification: Immunogen affinity purified.
• Form/Format: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
• Sequence Length: 1367

• Applicable Applications for anti-IGF1R antibody: IHC (Immunohistochemistry), WB (Western Blot)
• Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human IGF1 Receptor (1353-1367aa RKNERALPLPQSSTC), different from the related rat and mouse sequences by one amino acid.
• Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
• Relevant Detection Systems: The lab provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminsecence kit in Western Blot, supported by in IHC(P) and IHC(F).
• Preparation and Storage: At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.

IHC (Immunohiostchemistry)

(Anti-IGF1 Receptor antibody, AAA44925, IHC(P)IHC(P): Rat Pancreas Tissue)

WB (Western Blot)

(Anti-IGF1 Receptor antibody, AAA44925, Western blottingLane 1: 293T Cell LysateLane 2: A549 Cell LysateLane 3: MCF-7 Cell Lysate)

Related Product Information for anti-IGF1R antibody

Background: IGF1R(Insulin-like Growth Factor 1(IGF-1) Receptor) is a protein found on the surface of human cells. It is a transmembrane receptor that is activated by a hormone called Insulin-like growth factor 1(IGF-1) and by a related hormone called IGF-2. It belongs to the large class of tyrosine kinase receptors. The IGF1R gene is mapped on 15q26.3. IGF-1 plays an important role in growth and continues to have anabolic effects in adults - meaning that it can induce hypertrophy of skeletal muscle and other target tissues. Using a yeast 2-hybrid system, Dey et al.(1998) identified a regulatory subunit of phosphatidylinositol(PI) 3-kinase, PIK3R3, as a binding partner of IGF1R. Functional interaction between BRCA1 and SP1 in the regulation of the IGF1R gene was studied in Schneider cells, a Drosophila cell line which lacks endogenous SP1. In these cells, BRCA1 suppressed 45% of the SP1-induced trans-activation of the IGF1R promoter. Overexpression of the Grb10-binding fragment of Gigyf1 resulted in a significant increase in Igf1-stimulated Igf1r tyrosine phosphorylation. Like the insulin receptor, the IGF-1 receptor is a receptor tyrosine kinase - meaning it signals by causing the addition of a phosphate molecule on particular tyrosines. IGF-1 activates the Insulin receptor at approximately 0.1x the potency of insulin. Part of this signaling may be via IGF1R-InsulinReceptor heterodimers.

NCBI and Uniprot Product Information

• NCBI GI #: 124240
• NCBI GeneID: 3480
• UniProt Accession #: P08069; Q14CV2; Q9UCC0; B1B5Y2
• NCBI Official Full Name: Insulin-like growth factor 1 receptor
• NCBI Official Synonym Full Names: insulin-like growth factor 1 receptor
• NCBI Official Symbol: IGF1R
• NCBI Official Synonym Symbols: IGFR; CD221; IGFIR; JTK13
• NCBI Protein Information: insulin-like growth factor 1 receptor; IGF-I receptor; soluble IGF1R variant 1; soluble IGF1R variant 2; insulin-like growth factor I receptor
• UniProt Protein Name: Insulin-like growth factor 1 receptor
• UniProt Gene Name: IGF1R
• UniProt Synonym Gene Names: IGF-I receptor
• UniProt Entry Name: IGF1R_HUMAN