Rabbit anti-Human IKK beta Polyclonal Antibody | anti-IKBKB antibody

IKK beta Antibody

Cat. Num. AAA39811

• Gene Names: IKBKB; IKK2; IKKB; IMD15; NFKBIKB; IKK-beta
• Reactivity: Human
• Applications: Immunofluorescence, Immunocytochemistry, Western Blot, ELISA
• Purity: IKK beta Antibody is affinity chromatography purified via peptide column.
• Synonyms: IKK beta, Antibody; IKK beta Antibody; IKK beta; IKK2; IKKB; IMD15; NFKBIKB; IKK-beta; Inhibitor of nuclear factor kappa-B kinase subunit beta; I-kappa-B kinase 2; I-kappa-B-kinase beta; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta; anti-IKBKB antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: This polyclonal antibody has no cross response to IKKa or IKKy.
• Purity/Purification: IKK beta Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Sequence Length: 756

• Applicable Applications for anti-IKBKB antibody: IF (Immunofluorescence), ICC (Immunocytochemistry), WB (Western Blot), ELISA
• Conjugate: Unconjugated
• Immunogen: IKK beta antibody was raised against a peptide corresponding to amino acids near the carboxy terminus of human IKK beta (Genbank accession NoO14920), which differs from corresponding murine sequence by one amino acid.
• Buffer: IKK beta Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: IKK beta antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IF (Immunofluorescence)

(Immunofluorescence of IKK beta in Hela cells with IKK beta antibody at 10 μg/mL.)

ICC (Immunocytochemistry)

(Immunocytochemistry staining of HeLa cells using IKK beta antibody at 10 μg/mL.)

WB (Western Blot)

(Western blot analysis of IKK beta in Jurkat whole cell lysate with IKK beta antibody (C3) at 1:500 dilution.)

Related Product Information for anti-IKBKB antibody

IKK beta Antibody: Nuclear factor kappa B (NF-κB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-κB mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNFα, and bacteria product LPS. NF-κB is associated with IκB proteins in the cell cytoplasm, which inhibit NF-κB activity. The long-sought IκB kinase (IKK), which phosphorylates IκB, and mediates IκB degradation and NF-κB activation, was recently identified by several laboratories. IKK is a serine protein kinase, and the IKK complex contains alpha and beta subunits (IKKα and IKKβ). IKKα and IKKβ interact with each other and both are essential for NF-κB activation. IKKβ phosphorylates both IκB-alpha and IκB-beta. IKKβ is expressed in variety of human tissues.

NCBI and Uniprot Product Information

• NCBI GI #: 14285497
• NCBI GeneID: 3551
• UniProt Accession #: O14920; O75327; B4DZ30; B4E0U4
• Molecular Weight: 87 kDa
• NCBI Official Full Name: Inhibitor of nuclear factor kappa-B kinase subunit beta
• NCBI Official Synonym Full Names: inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
• NCBI Official Symbol: IKBKB
• NCBI Official Synonym Symbols: IKK2; IKKB; IMD15; NFKBIKB; IKK-beta
• NCBI Protein Information: inhibitor of nuclear factor kappa-B kinase subunit beta; IKK-B; I-kappa-B kinase 2; I-kappa-B-kinase beta; nuclear factor NF-kappa-B inhibitor kinase beta
• UniProt Protein Name: Inhibitor of nuclear factor kappa-B kinase subunit beta
• UniProt Gene Name: IKBKB
• UniProt Synonym Gene Names: IKKB; I-kappa-B-kinase beta; IKK-B; IKK-beta; IkBKB; IKK2; NFKBIKB
• UniProt Entry Name: IKKB_HUMAN