IF (Immunofluorescence)
(Immunofluorescence of IRF8 in K562 cells with IRF8 antibody at 10 μg/mL.)
Rabbit IRF8 Polyclonal Antibody | anti-IRF3 antibody
IRF8 Antibody
Gene Names
IRF8; ICSBP; IRF-8; ICSBP1; IMD32A; IMD32B; H-ICSBP
Reactivity
Human, Mouse, Rat
Applications
Immunofluorescence, Western Blot, ELISA
Purity
IRF8 Antibody is affinity chromatography purified via peptide column.
Synonyms
IRF8, Antibody; IRF8 Antibody; IRF8; Interferon regulatory factor 3; IRF-3; interferon regulatory factor 3; anti-IRF3 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
IRF8 Antibody is affinity chromatography purified via peptide column.
Form/Format
Liquid
Concentration
1 mg/mL (varies by lot)
Sequence Length
426
Applicable Applications for anti-IRF3 antibody
IF (Immunofluorescence), WB (Western Blot), ELISA
Conjugate
Unconjugated
Immunogen
IRF8 antibody was raised against a peptide corresponding to 16 amino acids near the carboxy terminus of human IRF8.
Buffer
IRF8 Antibody is supplied in PBS containing 0.02% sodium azide.
Preparation and Storage
IRF8 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
IF (Immunofluorescence)
(Immunofluorescence of IRF8 in K562 cells with IRF8 antibody at 10 μg/mL.)
IF (Immunofluorescence)
(Immunofluorescence of IRF8 in K562 cells with IRF8 antibody at 10 μg/mL.)
WB (Western Blot)
(Western blot analysis of IRF8 in human thymus tissue lysate with IRF8 antibody at 1μg/mL in (A) the presence and (B) absence of blocking peptide.)
WB (Western Blot)
(Western blot analysis of IRF8 in human thymus tissue lysate with IRF8 antibody at 1μg/mL in (A) the presence and (B) absence of blocking peptide.)
Related Product Information for anti-IRF3 antibody
IRF8 Antibody: Interferons (IFN)s are involved in a multitude of immune interactions during viral infections and play a major role in both the induction and regulation of innate and adaptive antiviral mechanisms. During infection, host-virus interactions signal downstream molecules such as transcription factors such as IFN regulatory factor-3 (IRF3) which can act to stimulate transcription of IFN-alpha/beta genes. Unlike IRF3, IRF8 appears to act as a negative regulator of IFN-induced genes in most cases, but IRF8 mediates activation of NF-κB by the toll-like receptor 9 (TLR9) after stimulation by unmethylated CpG DNA in dendritic cells. Finally, it has been shown that IRF8 decreases bcl-2 expression and thus may play a role in chronic myelogenous leukemia.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
48,356 Da
NCBI Official Full Name
interferon regulatory factor 8
NCBI Official Synonym Full Names
interferon regulatory factor 8
NCBI Official Symbol
IRF8
NCBI Official Synonym Symbols
ICSBP; IRF-8; ICSBP1; IMD32A; IMD32B; H-ICSBP
NCBI Protein Information
interferon regulatory factor 8; interferon consensus sequence binding protein 1
UniProt Protein Name
Interferon regulatory factor 8
UniProt Gene Name
IRF8
UniProt Synonym Gene Names
ICSBP1; IRF-8; H-ICSBP; ICSBP
UniProt Entry Name
IRF8_HUMAN
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Product Notes
The IRF3 irf8 (Catalog #AAA39630) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The IRF8 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's IRF8 can be used in a range of immunoassay formats including, but not limited to, IF (Immunofluorescence), WB (Western Blot), ELISA. Researchers should empirically determine the suitability of the IRF3 irf8 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "IRF8, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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