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IF (Immunofluorescence)
(Confocal immunofluorescent analysis of KChIP3 Antibody (N-term M1) with HepG2 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).)
Rabbit anti-Human, mouse KChIP3 Polyclonal Antibody | anti-KCNIP3 antibody
KChIP3 Antibody (N-term M1)
Gene Names
KCNIP3; CSEN; DREAM; KCHIP3
Reactivity
Human, mouse
Applications
Immunofluorescence, Immunohistochemistry, ELISA, Western Blot
Purity
Purified Rabbit Polyclonal Antibody (Pab)
Synonyms
KChIP3, Antibody; KChIP3 Antibody (N-term M1); Calsenilin; A-type potassium channel modulatory protein 3; DRE-antagonist modulator; DREAM; Kv channel-interacting protein 3; KChIP3; KCNIP3; CSEN; KCHIP3; anti-KCNIP3 antibody
Host
Rabbit
Reactivity
Human, mouse
Clonality
Polyclonal
Isotype
Rabbit Ig
Specificity
This KChIP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human KChIP3.
Purity/Purification
Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Concentration
Vial Concentration: 2 (varies by lot)
Sequence Positions
1-30
Sequence Length
230
Applicable Applications for anti-KCNIP3 antibody
IF (Immunofluorescence), IHC (Immunohistochemistry), ELISA, WB (Western Blot)
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
IF (Immunofluorescence)
(Confocal immunofluorescent analysis of KChIP3 Antibody (N-term M1) with HepG2 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).)
IF (Immunofluorescence)
(Confocal immunofluorescent analysis of KChIP3 Antibody (N-term M1) with HepG2 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).)
IHC (Immunohistochemisry)
(Formalin-fixed and paraffin-embedded human brain tissue reacted with KChIP3 Antibody (N-term M1) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.)
IHC (Immunohistochemisry)
(Formalin-fixed and paraffin-embedded human brain tissue reacted with KChIP3 Antibody (N-term M1) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.)
IHC (Immunohiostchemistry)
(Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.)
IHC (Immunohiostchemistry)
(Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.)
WB (Western Blot)
(Western blot analysis of KChIP3 Antibody (N-term M1) in mouse heart tissue lysates (35ug/lane). KChIP3(arrow) was detected using the purified Pab.)
WB (Western Blot)
(Western blot analysis of KChIP3 Antibody (N-term M1) in mouse heart tissue lysates (35ug/lane). KChIP3(arrow) was detected using the purified Pab.)
Related Product Information for anti-KCNIP3 antibody
KChIP3 is a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. This protein is also shown to function as a calcium-regulated transcriptional repressor, and to interact with presenilins. Mutations in the presenilin genes have been implicated in Alzheimer's disease. Due to utilization of an alternate in-frame translation start codon, the gene for this protein encodes two isoforms with different sizes.
Product Categories/Family for anti-KCNIP3 antibody
References
Choi, E.K., et al., Mol. Cell. Neurosci. 23(3):495-506 (2003).
Hong, Y.M., et al., Neurosci. Lett. 340(1):33-36 (2003).
Schrader, L.A., et al., J. Neurosci. 22(23):10123-10133 (2002).
Lilliehook, C., et al., Mol. Cell. Neurosci. 19(4):552-559 (2002).
Cheng, H.Y., et al., Cell 108(1):31-43 (2002).
Hong, Y.M., et al., Neurosci. Lett. 340(1):33-36 (2003).
Schrader, L.A., et al., J. Neurosci. 22(23):10123-10133 (2002).
Lilliehook, C., et al., Mol. Cell. Neurosci. 19(4):552-559 (2002).
Cheng, H.Y., et al., Cell 108(1):31-43 (2002).
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
29231
NCBI Official Full Name
calsenilin isoform 2
NCBI Official Synonym Full Names
Kv channel interacting protein 3, calsenilin
NCBI Official Symbol
KCNIP3
NCBI Official Synonym Symbols
CSEN; DREAM; KCHIP3
NCBI Protein Information
calsenilin
UniProt Protein Name
Calsenilin
UniProt Gene Name
KCNIP3
UniProt Synonym Gene Names
CSEN; DREAM; KCHIP3; DREAM; KChIP3
UniProt Entry Name
CSEN_HUMAN
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Product Notes
The KCNIP3 kcnip3 (Catalog #AAA286473) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-30. The KChIP3 Antibody (N-term M1) reacts with Human, mouse and may cross-react with other species as described in the data sheet. AAA Biotech's KChIP3 can be used in a range of immunoassay formats including, but not limited to, IF (Immunofluorescence), IHC (Immunohistochemistry), ELISA, WB (Western Blot). Researchers should empirically determine the suitability of the KCNIP3 kcnip3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "KChIP3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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