Rabbit KDR Polyclonal Antibody | anti-KDR antibody

KDR Polyclonal Antibody

Cat. Num. AAA268847

• Gene Names: KDR; FLK1; CD309; VEGFR; VEGFR2
• Reactivity: Human, Mouse, Rat, Fish
• Applications: ELISA, Immunohistochemistry, Immunofluorescence, Western Blot
• Synonyms: KDR, Antibody; KDR Polyclonal Antibody; anti-KDR antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat, Fish
• Clonality: Polyclonal
• Isotype: IgG
• Form/Format: Liquid in PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Sequence Length: 1356

• Applicable Applications for anti-KDR antibody: ELISA, IHC (Immunohistochemistry), IF (Immunofluorescence), WB (Western Blot)
• Immunogen: A synthetic peptide of human KDR (NP_002244.1).
• Cellular Localization: Cell junction . Endoplasmic reticulum . Cell membrane . Localized with RAP1A at cell-cell junctions (By similarity). Colocalizes with ERN1 and XBP1 in the endoplasmic reticulum in endothelial cells in a vascular endothelial growth factor (VEGF)-dependent manner (PubMed:23529610). .; [Isoform 1]: Cell membrane; Single-pass type I membrane protein. Cytoplasm. Nucleus. Cytoplasmic vesicle. Early endosome. Detected on caveolae-enriched lipid rafts at the cell surface. Is recycled from the plasma membrane to endosomes and back again. Phosphorylation triggered by VEGFA binding promotes internalization and subsequent degradation. VEGFA binding triggers internalization and translocation to the nucleus.; [Isoform 2]: Secreted .; [Isoform 3]: Secreted
• Tissue specificity: Detected in cornea (at protein level). Widely expressed.
• Function: Catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,Function: Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 7 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Interacts with MYOF (By similarity). Interacts with SHB; upon VEGF activation. Interacts with HIV-1 Tat
• Preparation and Storage: Store at -15°C to -25°C (Do not lower than -25°C). Avoid freeze/thaw cycles.

IHC (Immunohiostchemistry)

(Immunohistochemistry analysis of paraffin- embedded human brain tissue, using VEGFR2 Antibody. The picture on the right is blocked with the synthesized peptide.)

WB (Western Blot)

(Western Blot analysis of Hela cells using Flk-1 Polyclonal Antibody diluted at 1:1000.)

NCBI and Uniprot Product Information

• NCBI GI #: 11321597
• NCBI GeneID: 3791
• NCBI Accession #: NP_002244.1
• NCBI GenBank Nucleotide #: NP_002244.1
• UniProt Accession #: P35968
• Molecular Weight: 151kD
• NCBI Official Full Name: vascular endothelial growth factor receptor 2
• NCBI Official Synonym Full Names: kinase insert domain receptor
• NCBI Official Symbol: KDR
• NCBI Official Synonym Symbols: FLK1; CD309; VEGFR; VEGFR2
• NCBI Protein Information: vascular endothelial growth factor receptor 2
• UniProt Protein Name: Vascular endothelial growth factor receptor 2
• UniProt Gene Name: KDR
• UniProt Synonym Gene Names: FLK1; VEGFR2; VEGFR-2; FLK-1; KDR
• UniProt Entry Name: VGFR2_HUMAN