Rabbit LAMC1 Polyclonal Antibody | anti-LAMC1 antibody

LAMC1 Rabbit Polyclonal Antibody

Cat. Num. AAA313632

• Gene Names: LAMC1; LAMB2
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry, Western Blot
• Purity: Affinity purification
• Synonyms: LAMC1, Antibody; LAMC1 Rabbit Polyclonal Antibody; LAMC1; LAMB2; anti-LAMC1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity purification
• Form/Format: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Applicable Applications for anti-LAMC1 antibody: IHC (Immunohistochemistry), WB (Western Blot)
• Immunogen: Recombinant fusion protein of human LAMC1 (NP_002284.3).
• Preparation and Storage: Store at -20 degree C. Avoid freeze/thaw cycles.

IHC (Immunohistochemistry)

(Immunohistochemistry of paraffin-embedded human uterus using LAMC1 antibody.)

IHC (Immunohistochemistry)

(Immunohistochemistry of paraffin-embedded human uterine cancer using LAMC1 antibody.)

IHC (Immunohistochemisry)

(Immunohistochemistry of paraffin-embedded human breast cancer using LAMC1 antibody.)

WB (Western Blot)

(Western blot analysis of extracts of LO2 cells, using LAMC1 antibody.)

WB (Western Blot)

(Western blot analysis of extracts of various cell lines, using LAMC1 antibody.)

Related Product Information for anti-LAMC1 antibody

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins, composed of 3 non identical chains: laminin alpha, beta and gamma. Some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the gamma chain isoform laminin, gamma 1. The gamma 1 chain, formerly thought to be a beta chain, contains structural domains similar to beta chains, however, lacks the short alpha region separating domains I and II. The structural organization of this gene also suggested that it had diverged considerably from the beta chain genes. Embryos of transgenic mice in which both alleles of the gamma 1 chain gene were inactivated by homologous recombination, lacked basement membranes, indicating that laminin, gamma 1 chain is necessary for laminin heterotrimer assembly. It has been inferred by analogy with the strikingly similar 3' UTR sequence in mouse laminin gamma 1 cDNA, that multiple polyadenylation sites are utilized in human to generate the 2 different sized mRNAs (5.5 and 7.5 kb) seen on Northern analysis.

Product Categories/Family for anti-LAMC1 antibody

Primary Antibody

NCBI and Uniprot Product Information

• NCBI GI #: 145309326
• NCBI GeneID: 3915
• NCBI Accession #: NP_002284.3
• NCBI GenBank Nucleotide #: NM_002293.3
• UniProt Accession #: P11047; Q5VYE7
• Molecular Weight: 177,603 Da
• NCBI Official Full Name: laminin subunit gamma-1
• NCBI Official Synonym Full Names: laminin, gamma 1 (formerly LAMB2)
• NCBI Official Symbol: LAMC1
• NCBI Official Synonym Symbols: LAMB2
• NCBI Protein Information: laminin subunit gamma-1; S-LAM gamma; laminin B2 chain; S-laminin subunit gamma; laminin-2 subunit gamma; laminin-3 subunit gamma; laminin-4 subunit gamma; laminin-6 subunit gamma; laminin-7 subunit gamma; laminin-8 subunit gamma; laminin-9 subunit gamma
• UniProt Protein Name: Laminin subunit gamma-1
• UniProt Gene Name: LAMC1
• UniProt Synonym Gene Names: LAMB2; S-LAM gamma
• UniProt Entry Name: LAMC1_HUMAN