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IHC (Immunohistochemistry)
(LPAR6 Antibdy (Center) (AAA289067) immunohistochemistry analysis in formalin fixed and paraffin embedded human breast carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of LPAR6 Antibdy (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)
Rabbit LPAR6 Polyclonal Antibody | anti-LPAR6 antibody
LPAR6 Antibody (Center)
Gene Names
LPAR6; LAH3; P2Y5; ARWH1; HYPT8; P2RY5
Reactivity
Human, Mouse, RatPredicted: Rat
Applications
ELISA, Immunohistochemistry, Western Blot
Purity
This antibody is purified through a protein A column, followed by peptide affinity purification.
Synonyms
LPAR6, Antibody; LPAR6 Antibody (Center); Lysophosphatidic acid receptor 6; LPA receptor 6; LPA-6; Oleoyl-L-alpha-lysophosphatidic acid receptor; P2Y purinoceptor 5; P2Y5; Purinergic receptor 5; RB intron encoded G-protein coupled receptor; LPAR6; P2RY5; anti-LPAR6 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Predicted: Rat
Predicted: Rat
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
This LPAR6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 106-134 amino acids from the Central region of human LPAR6.
Purity/Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
Sequence Positions
106-134
Sequence Length
344
Applicable Applications for anti-LPAR6 antibody
ELISA, IHC (Immunohistochemistry), WB (Western Blot)
Function
Binds to oleoyl-L-alpha-lysophosphatidic acid (LPA). Intracellular cAMP is involved in the receptor activation. Important for the maintenance of hair growth and texture.
Cellular Location
Cell membrane; Multi-pass membrane protein
Tissue Location
Expressed ubiquitously, including in skin and hair follicle cells. Detected in both Henle's and Huxley's layers of the inner root sheath of the hair follicle and in suprabasal layers of the epidermis (at protein level). Expressed at low levels in peripheral blood leukocytes.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 2 weeks. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
IHC (Immunohistochemistry)
(LPAR6 Antibdy (Center) (AAA289067) immunohistochemistry analysis in formalin fixed and paraffin embedded human breast carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of LPAR6 Antibdy (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)
IHC (Immunohistochemistry)
(LPAR6 Antibdy (Center) (AAA289067) immunohistochemistry analysis in formalin fixed and paraffin embedded human breast carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of LPAR6 Antibdy (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)
WB (Western Blot)
(LPAR6 Antibody (Center) (AAA289067) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the LPAR6 antibody detected the LPAR6 protein (arrow).)
WB (Western Blot)
(LPAR6 Antibody (Center) (AAA289067) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the LPAR6 antibody detected the LPAR6 protein (arrow).)
WB (Western Blot)
(All lanes : Anti-LPAR6 Antibody (Center) at 1:1000 dilutionLane 1: Mouse heart tissue lysateLane 2: Rat heart tissue lysateLysates/proteins at 20 ug per lane.Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution.Predicted band size : 39 kDaBlocking/Dilution buffer: 5% NFDM/TBST.)
WB (Western Blot)
(All lanes : Anti-LPAR6 Antibody (Center) at 1:1000 dilutionLane 1: Mouse heart tissue lysateLane 2: Rat heart tissue lysateLysates/proteins at 20 ug per lane.Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution.Predicted band size : 39 kDaBlocking/Dilution buffer: 5% NFDM/TBST.)
WB (Western Blot)
(All lanes : Anti-LPAR6 Antibody (Center) at 1:2000 dilutionLane 1: Molt-4 whole cell lysateLane 2: HepG2 whole cell lysateLane 3: Mouse heart tissue lysateLysates/proteins at 20 ug per lane.Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution.Predicted band size : 39 kDaBlocking/Dilution buffer: 5% NFDM/TBST.)
WB (Western Blot)
(All lanes : Anti-LPAR6 Antibody (Center) at 1:2000 dilutionLane 1: Molt-4 whole cell lysateLane 2: HepG2 whole cell lysateLane 3: Mouse heart tissue lysateLysates/proteins at 20 ug per lane.Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution.Predicted band size : 39 kDaBlocking/Dilution buffer: 5% NFDM/TBST.)
Related Product Information for anti-LPAR6 antibody
The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene aligns with an internal intron of the retinoblastoma susceptibility gene in the reverse orientation. Alternative splicing results in multiple transcript variants.
Product Categories/Family for anti-LPAR6 antibody
References
Pasternack, S.M., et al. Arch. Dermatol. Res. 301(8):621-624(2009)
Yanagida, K., et al. J. Biol. Chem. 284(26):17731-17741(2009)
Tariq, M., et al. Br. J. Dermatol. 160(5):1006-1010(2009)
Shimomura, Y., et al. J. Invest. Dermatol. 129(3):622-628(2009)
Dereure, O. Ann Dermatol Venereol 135(11):794-795(2008)
Yanagida, K., et al. J. Biol. Chem. 284(26):17731-17741(2009)
Tariq, M., et al. Br. J. Dermatol. 160(5):1006-1010(2009)
Shimomura, Y., et al. J. Invest. Dermatol. 129(3):622-628(2009)
Dereure, O. Ann Dermatol Venereol 135(11):794-795(2008)
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
NCBI Official Full Name
lysophosphatidic acid receptor 6
NCBI Official Synonym Full Names
lysophosphatidic acid receptor 6
NCBI Official Symbol
LPAR6
NCBI Official Synonym Symbols
LAH3; P2Y5; ARWH1; HYPT8; P2RY5
NCBI Protein Information
lysophosphatidic acid receptor 6
UniProt Protein Name
Lysophosphatidic acid receptor 6
UniProt Gene Name
LPAR6
UniProt Synonym Gene Names
P2RY5; LPA receptor 6; LPA-6; P2Y5
UniProt Entry Name
LPAR6_HUMAN
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Product Notes
The LPAR6 lpar6 (Catalog #AAA289067) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 106-134. The LPAR6 Antibody (Center) reacts with Human, Mouse, Rat Predicted: Rat and may cross-react with other species as described in the data sheet. AAA Biotech's LPAR6 can be used in a range of immunoassay formats including, but not limited to, ELISA, IHC (Immunohistochemistry), WB (Western Blot). Researchers should empirically determine the suitability of the LPAR6 lpar6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "LPAR6, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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