IHC (Immunohiostchemistry)
(Detection of human NP95/UHRF1 by immunohistochemistry. Sample: FFPE section of human breast carcinoma. Antibody: Affinity purified rabbit anti-NP95/UHRF1 (Cat. No. AAA214075) used at a dilution of 1:250. Detection: DAB)
Rabbit anti-Human NP95/UHRF1 Polyclonal Antibody | anti-NP95/UHRF1 antibody
Rabbit anti-NP95/UHRF1 IHC Antibody, Affinity Purified
Gene Names
UHRF1; Np95; hNP95; ICBP90; RNF106; hUHRF1
Reactivity
Human
Applications
Immunohistochemistry
Purity
Antigen Affinity Purified
Synonyms
NP95/UHRF1, Antibody; Rabbit anti-NP95/UHRF1 IHC Antibody, Affinity Purified; RNF106; Ubiquitin-like-containing PHD and RING finger domains protein 1; ubiquitin-like PHD and RING finger domain-containing protein 1; TDRD22; RING-type E3 ubiquitin transferase UHRF1; RING finger protein 106; nuclear zinc finger protein Np95; nuclear protein 95; Np95; inverted CCAAT box-binding protein of 90 kDa; ICBP90; huNp95; hUHRF1; hNP95; E3 ubiquitin-protein ligase UHRF1; transcription factor ICBP90; nuclear phosphoprotein 95; ubiquitin like with PHD and ring finger domains 1; anti-NP95/UHRF1 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Purity/Purification
Antigen Affinity Purified
Form/Format
Liquid. Whole IgG. Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide
Concentration
250ug/ml (varies by lot)
Applicable Applications for anti-NP95/UHRF1 antibody
IHC (Immunohistochemistry)
Predicted Reactivity
Orangutan, Monkey, Gorilla, Chimpanzee, Crab-eating macaque, Northern white-cheeked gibbon, White-tufted-ear marmoset
Immunogen
Between 275 and 325
Conjugation
Unconjugated
Preparation and Storage
Store at 2-8 degree C
Shelf Life: 1 year from date of receipt
Shelf Life: 1 year from date of receipt
IHC (Immunohiostchemistry)
(Detection of human NP95/UHRF1 by immunohistochemistry. Sample: FFPE section of human breast carcinoma. Antibody: Affinity purified rabbit anti-NP95/UHRF1 (Cat. No. AAA214075) used at a dilution of 1:250. Detection: DAB)
IHC (Immunohiostchemistry)
(Detection of human NP95/UHRF1 by immunohistochemistry. Sample: FFPE section of human breast carcinoma. Antibody: Affinity purified rabbit anti-NP95/UHRF1 (Cat. No. AAA214075) used at a dilution of 1:250. Detection: DAB)
IHC (Immunohistochemistry)
(Detection of human NP95/UHRF1 by immunohistochemistry. Sample: FFPE section of human basal cell carcinoma. Antibody: Affinity purified rabbit anti-NP95/UHRF1 (Cat. No. AAA214075) used at a dilution of 1:250. Detection: DAB)
IHC (Immunohistochemistry)
(Detection of human NP95/UHRF1 by immunohistochemistry. Sample: FFPE section of human basal cell carcinoma. Antibody: Affinity purified rabbit anti-NP95/UHRF1 (Cat. No. AAA214075) used at a dilution of 1:250. Detection: DAB)
Related Product Information for anti-NP95/UHRF1 antibody
NP95/UHRF1 was originally identified as ICBP90 (inverted CCAAT box-binding protein of 90 kDa) in a one-hybrid screen for proteins that bind the topoisomerase IIalpha gene promoter. NP95/UHRF1 is a heterochromatin binding protein that directly interacts with histones and has proposed roles in the DNA damage response, heterochromatin formation, and cell replication. Structurally, NP95/UHRF1 contains an ubiquitin-like domain (NIRF_N), a plant homeodomain (PHD), a SRA domain, and a RING domain. The RING domain imparts ubiquitin E3 ligase activity that is histone-specific. This E3 ligase activity is proposed to be important to tumor growth. NP95/UHRF1 expression begins in the G1/S phase and continues through mitosis. It has been shown to be required for entry from G1/G0 as well as the G1/S transition in some cell types. NP95/UHRF1 has been found to be part of the pericentric heterochromatin duplication body (pHDB) and involved in the replication and formation of heterochromatin.
Product Categories/Family for anti-NP95/UHRF1 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
Observed Molecular Weight The band size is ~90kDa
NCBI Official Full Name
E3 ubiquitin-protein ligase UHRF1 isoform 1
NCBI Official Synonym Full Names
ubiquitin-like with PHD and ring finger domains 1
NCBI Official Symbol
UHRF1
NCBI Official Synonym Symbols
Np95; hNP95; ICBP90; RNF106; hUHRF1
NCBI Protein Information
E3 ubiquitin-protein ligase UHRF1; huNp95; nuclear protein 95; RING finger protein 106; transcription factor ICBP90; nuclear zinc finger protein Np95; inverted CCAAT box-binding protein of 90 kDa; ubiquitin-like, containing PHD and RING finger domains, 1;
UniProt Protein Name
E3 ubiquitin-protein ligase UHRF1
UniProt Gene Name
UHRF1
UniProt Synonym Gene Names
ICBP90; NP95; RNF106; HuNp95; hNp95; hUHRF1
UniProt Entry Name
UHRF1_HUMAN
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Product Notes
The NP95/UHRF1 uhrf1 (Catalog #AAA214075) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit anti-NP95/UHRF1 IHC Antibody, Affinity Purified reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's NP95/UHRF1 can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry). Researchers should empirically determine the suitability of the NP95/UHRF1 uhrf1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "NP95/UHRF1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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