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WB (Western Blot)
(NR4A2 Antibody (N-term) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the NR4A2 antibody detected the NR4A2 protein (arrow).)
Rabbit NURR1 (NR4A2) Polyclonal Antibody | anti-NR4A2 antibody
NURR1 (NR4A2) Antibody (N-term)
Gene Names
NR4A2; NOT; RNR1; HZF-3; NURR1; TINUR
Reactivity
Human, mouse (Predicted Reactivity: Bovine, Rat)
Applications
Western Blot, Immunofluorescence, Immunohistochemistry, ELISA
Purity
Purified Rabbit Polyclonal Antibody (Pab)
Synonyms
NURR1 (NR4A2), Antibody; NURR1 (NR4A2) Antibody (N-term); Nuclear receptor subfamily 4 group A member 2; Immediate-early response protein NOT; Orphan nuclear receptor NURR1; Transcriptionally-inducible nuclear receptor; NR4A2; NOT; NURR1; TINUR; anti-NR4A2 antibody
Host
Rabbit
Reactivity
Human, mouse (Predicted Reactivity: Bovine, Rat)
Clonality
Polyclonal
Isotype
Rabbit Ig
Specificity
This NURR1 (NR4A2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 13-42 amino acids from the N-terminal region of human NURR1 (NR4A2).
Purity/Purification
Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Concentration
Vial Concentration: 2 (varies by lot)
Sequence Positions
13-42
Sequence Length
535
Applicable Applications for anti-NR4A2 antibody
WB (Western Blot), IF (Immunofluorescence), IHC (Immunohistochemistry), ELISA
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
WB (Western Blot)
(NR4A2 Antibody (N-term) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the NR4A2 antibody detected the NR4A2 protein (arrow).)
WB (Western Blot)
(NR4A2 Antibody (N-term) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the NR4A2 antibody detected the NR4A2 protein (arrow).)
IF (Immunofluorescence)
(Confocal immunofluorescent analysis of NURR1 (NR4A2) Antibody (N-term) with Hela cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).)
IF (Immunofluorescence)
(Confocal immunofluorescent analysis of NURR1 (NR4A2) Antibody (N-term) with Hela cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).)
IHC (Immunohiostchemistry)
(Formalin-fixed and paraffin-embedded human brain tissue reacted with NURR1 (NR4A2) antibody (N-term) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.)
IHC (Immunohiostchemistry)
(Formalin-fixed and paraffin-embedded human brain tissue reacted with NURR1 (NR4A2) antibody (N-term) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.)
WB (Western Blot)
(Western blot analysis of anti-NURR1(NR4A2) Pab in mouse brain tissue lysate. NURR1(NR4A2) (arrow) was detected using the purified Pab.)
WB (Western Blot)
(Western blot analysis of anti-NURR1(NR4A2) Pab in mouse brain tissue lysate. NURR1(NR4A2) (arrow) was detected using the purified Pab.)
Related Product Information for anti-NR4A2 antibody
Parkinson's disease (PD) is a multifactorial disease that appears to arise from the effects of both genetic and environmental influences. The known genetic factors include multiple genes that have been identified in related parkinsonian syndromes, as well as alpha-synuclein. Genes associated with either PD or Parkinson-related disorders include parkin, DJ-1, ubiquitin C-terminal hydrolase isozyme L1 (UCH-L1), nuclear receptor-related factor 1 (NURR1), and alpha-synuclein. Nurr1 is a transcription factor that is expressed in the embryonic ventral midbrain and is critical for the development of dopamine (DA) neurons. It belongs to the conserved family of nuclear receptors but lacks an identified ligand and is therefore referred to as an orphan receptor. RXR ligands can promote the survival of DA neurons via a process that depends on Nurr1-RXR heterodimers. In developing DA cells, Nurr1 is required for the expression of several genes important for DA synthesis and function. Nurr1 is also important for the maintenance of adult DA neurons.
Product Categories/Family for anti-NR4A2 antibody
References
Perlmann T, et al. Cell Tissue Res. 318(1):45-52 (2004) Hsu HC,et al. Curr Drug Targets Inflamm Allergy. 3(4):413-23 (2004) Wallen-Mackenzie A, et al. Genes Dev. 17(24):3036-47 (2003) Ichinose,H., et al. Gene 230 (2), 233-239 (1999) Okabe,T., et al. J. Immunol. 154 (8), 3871-3879 (1995) Mages,H.W., et al. Mol. Endocrinol. 8 (11), 1583-1591 (1994)
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
66591
NCBI Official Full Name
nuclear receptor subfamily 4 group A member 2
NCBI Official Synonym Full Names
nuclear receptor subfamily 4, group A, member 2
NCBI Official Symbol
NR4A2
NCBI Official Synonym Symbols
NOT; RNR1; HZF-3; NURR1; TINUR
NCBI Protein Information
nuclear receptor subfamily 4 group A member 2
UniProt Protein Name
Nuclear receptor subfamily 4 group A member 2
UniProt Gene Name
NR4A2
UniProt Synonym Gene Names
NOT; NURR1; TINUR
UniProt Entry Name
NR4A2_HUMAN
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Product Notes
The NR4A2 nr4a2 (Catalog #AAA286182) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 13-42. The NURR1 (NR4A2) Antibody (N-term) reacts with Human, mouse (Predicted Reactivity: Bovine, Rat) and may cross-react with other species as described in the data sheet. AAA Biotech's NURR1 (NR4A2) can be used in a range of immunoassay formats including, but not limited to, WB (Western Blot), IF (Immunofluorescence), IHC (Immunohistochemistry), ELISA. Researchers should empirically determine the suitability of the NR4A2 nr4a2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "NURR1 (NR4A2), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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