Rabbit OLIG2 Polyclonal Antibody | anti-OLIG2 antibody

OLIG2 Antibody

Cat. Num. AAA40492

• Gene Names: OLIG2; BHLHB1; OLIGO2; RACK17; PRKCBP2; bHLHe19
• Reactivity: Human, Mouse, Rat
• Applications: Immunofluorescence, Immunohistochemistry, Western Blot, ELISA
• Purity: OLIG2 antibody is affinity chromatography purified via peptide column.
• Synonyms: OLIG2, Antibody; OLIG2 Antibody; OLIG2; BHLHB1; OLIGO2; RACK17; PRKCBP2; bHLHe19; BHLHE19; Oligodendrocyte transcription factor 2; Class B basic helix-loop-helix protein 1; Oligo2; oligodendrocyte lineage transcription factor 2; anti-OLIG2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: OLIG2 antibody is human, mouse and rat reactive. It is predicted to not cross-react with other members of the OLIG family of proteins. At least three isoforms of OLIG2 are known to exist; this antibody will detect all three isoforms.
• Purity/Purification: OLIG2 antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 323

• Applicable Applications for anti-OLIG2 antibody: IF (Immunofluorescence), IHC (Immunohistochemistry), WB (Western Blot), ELISA
• Conjugate: Unconjugated
• Immunogen: OLIG2 antibody was raised against a 15 amino acid peptide near the amino terminus of human OLIG2.
• Buffer: OLIG2 Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: OLIG2 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year.

IF (Immunofluorescence)

(Immunofluorescence of OLIG2 in mouse brain tissue with OLIG2 Antibody at 20 μg/mL.Green: OLIG2 antibody (7743)Red: Phylloidin stainingBlue: DAPI staining)

IHC (Immunohistochemistry)

(Immunohistochemistry of OLIG2 in mouse brain tissue with OLIG2 Antibody at 5 μg/mL.)

IF (Immunofluorescence)

(Immunofluorescence of OLIG2 in rat brain tissue with OLIG2 antibody at 20 μg/mL.)

IHC (Immunohiostchemistry)

(Immunohistochemistry of OLIG2 in rat brain tissue with OLIG2 antibody at 5 μg/mL.)

WB (Western Blot)

(Western blot analysis of OLIG2 in EL4 cell lysate with OLIG2 antibody at 1 μg/ml in (A) the absence and (B) the presence of blocking peptide.)

Related Product Information for anti-OLIG2 antibody

The oligodendrocyte transcription factors 1 and 2 (OLIG1 and OLIG2, respectively) make up part of basic helix-loop-helix (bHLH) family of transcription factors that are specifically expressed in zones of the neuroepithelium from which oligodendrocyte precursors emerge (1). Both OLIG1 and OLIG2 genes are downstream targets of Sonic hedgehog and are expressed exclusively in the central nervous system (2). OLIG2 is first observed in the ventral most p3 progenitor domain of the ventral neural tube while OLIG1 is first expressed in the dorsal portion of the p3 domain (2). Mice overexpressing OLIG2 exhibit impaired potassium channel expression in neural progenitors and proliferation of these cells similar to that seen in Down Syndrome, suggesting that OLIG2 may play a role in this pathology (3).

NCBI and Uniprot Product Information

• NCBI GI #: 17978475
• NCBI GeneID: 10215
• NCBI Accession #: NP_005797
• NCBI GenBank Nucleotide #: NM_005806.3
• UniProt Accession #: Q13516; Q05BP9; Q49AL3; Q86X04; Q9NZ14; B3KRF3
• Molecular Weight: Predicted: 36 kDa; ; Observed: 37 kDa
• NCBI Official Full Name: oligodendrocyte transcription factor 2
• NCBI Official Synonym Full Names: oligodendrocyte lineage transcription factor 2
• NCBI Official Symbol: OLIG2
• NCBI Official Synonym Symbols: BHLHB1; OLIGO2; RACK17; PRKCBP2; bHLHe19
• NCBI Protein Information: oligodendrocyte transcription factor 2; protein kinase C-binding protein 2; class B basic helix-loop-helix protein 1; class E basic helix-loop-helix protein 19; human protein kinase C-binding protein RACK17; basic domain, helix-loop-helix protein, class B, 1; oligodendrocyte-specific bHLH transcription factor 2
• UniProt Protein Name: Oligodendrocyte transcription factor 2
• UniProt Gene Name: OLIG2
• UniProt Synonym Gene Names: BHLHB1; BHLHE19; PRKCBP2; RACK17; Oligo2; bHLHb1; bHLHe19
• UniProt Entry Name: OLIG2_HUMAN