Rabbit anti-Human PAK5 Polyclonal Antibody | anti-PAK7 antibody

PAK5 Antibody

Cat. Num. AAA39695

• Gene Names: PAK7; PAK5
• Reactivity: Human
• Applications: Immunofluorescence, Immunocytochemistry, Western Blot, ELISA
• Purity: PAK5 Antibody is affinity chromatography purified via peptide column.
• Synonyms: PAK5, Antibody; PAK5 Antibody; PAK5; KIAA1264; p21-activated kinase 5; PAK-5; p21 protein (Cdc42/Rac)-activated kinase 7; anti-PAK7 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: PAK5 Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 719

• Applicable Applications for anti-PAK7 antibody: IF (Immunofluorescence), ICC (Immunocytochemistry), WB (Western Blot), ELISA
• Conjugate: Unconjugated
• Immunogen: PAK5 antibody was raised against a 13 amino acid synthetic peptide from near the center of human PAK5.
• Buffer: PAK5 Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: Antibody can be stored at 4 degree C up to one year. Antibodies should not be exposed to prolonged high temperatures.

IF (Immunofluorescence)

(Immunofluorescence of PAK5 in K562 cells with PAK5 antibody at 10 μg/mL.)

ICC (Immunocytochemistry)

(Immunocytochemistry of PAK5 in K562 cells with PAK5 antibody at 2 μg/mL.)

WB (Western Blot)

(Western blot analysis of PAK5 in T24 lysate with PAK5 antibody at (A) 2 and (B) 4 μg/mL.)

Related Product Information for anti-PAK7 antibody

PAK5 Antibody: The p21-activated kinases (PAKs) are serine-threonine kinases that bind to the active forms of Cdc42 and Rac. They are divided into two groups, the first of which include PAK1, 2 and 3, and can be activated by Cdc42/Rac binding. Group 1 PAKs contain an autoinhibitory domain whose activity is regulated by Cdc42/Rac binding. The group 1 PAKs are known to be involved in cellular processes such as gene transcription, apoptosis, and cell morphology and motility. Much less is known about the second group, which includes PAK4, 5 and 6. These proteins are not activated by Cdc42/Rac binding. PAK5 was initially identified as a kinase expressed primarily in brain that while possessing a kinase domain and GTPase binding domain similar to PAK4 and PAK6, is completely different from both. Expression of PAK5 in neural based cell lines resulted in neurite outgrowth suggesting that PAK5 may be involved in regulating the cytoskeletal changes necessary for promoting neurite outgrowth. Other experiments suggest that unlike the other PAKs, PAK5 may inhibit apoptosis by phosphorylating the Bcl-2 family member Bad.

NCBI and Uniprot Product Information

• NCBI GI #: 12585290
• NCBI GeneID: 57144
• UniProt Accession #: Q9P286; Q5W115; Q9BX09; Q9ULF6; A8K5T6; D3DW14
• Molecular Weight: 80,745 Da
• NCBI Official Full Name: Serine/threonine-protein kinase PAK 7
• NCBI Official Synonym Full Names: p21 protein (Cdc42/Rac)-activated kinase 7
• NCBI Official Symbol: PAK7
• NCBI Official Synonym Symbols: PAK5
• NCBI Protein Information: serine/threonine-protein kinase PAK 7; PAK-5; PAK-7; protein kinase PAK5; p21-activated kinase 5; p21-activated kinase 7; p21CDKN1A-activated kinase 7; serine/threonine-protein kinase PAK7
• UniProt Protein Name: Serine/threonine-protein kinase PAK 7
• UniProt Gene Name: PAK7
• UniProt Synonym Gene Names: KIAA1264; PAK5; PAK-5; PAK-7
• UniProt Entry Name: PAK7_HUMAN