IF (Immunofluorescence)
(Immunofluorescence analysis of HUVEC cells, using PTTG1 antibody.)
Rabbit anti-Human PTTG1 Polyclonal Antibody | anti-PTTG1 antibody
PTTG1 Antibody
Gene Names
PTTG1; EAP1; PTTG; HPTTG; TUTR1
Reactivity
Human
Applications
Immunofluorescence, Western Blot
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Synonyms
PTTG1, Antibody; PTTG1 Antibody; EAP1; PTTG; PTTG1; TUTR1; anti-PTTG1 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Specificity
The antibody detects endogenous levels of total PTTG1 protein.
Purity/Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1.0 mg/ml (varies by lot)
Sequence Length
202
Applicable Applications for anti-PTTG1 antibody
IF (Immunofluorescence), WB (Western Blot)
Immunogen Type
Peptide
Immunogen Description
Synthesized peptide derived from internal of human PTTG1.
Target Name
PTTG1
Preparation and Storage
Store at -20 degree C
IF (Immunofluorescence)
(Immunofluorescence analysis of HUVEC cells, using PTTG1 antibody.)
IF (Immunofluorescence)
(Immunofluorescence analysis of HUVEC cells, using PTTG1 antibody.)
WB (Western Blot)
(Western blot analysis of extracts from 293 cells, Jurkat cells and HepG2 cells, using PTTG1 antibody.)
WB (Western Blot)
(Western blot analysis of extracts from 293 cells, Jurkat cells and HepG2 cells, using PTTG1 antibody.)
Related Product Information for anti-PTTG1 antibody
Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of TP53. The negative regulation of TP53 may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid separation.Dominguez A., Oncogene 17:2187-2193(1998).Kakar S.S., Cytogenet. Cell Genet. 84:211-216(1999).Zhang X., Mol. Endocrinol. 13:156-166(1999).
Product Categories/Family for anti-PTTG1 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
22,024 Da
NCBI Official Full Name
securin
NCBI Official Synonym Full Names
pituitary tumor-transforming 1
NCBI Official Symbol
PTTG1
NCBI Official Synonym Symbols
EAP1; PTTG; HPTTG; TUTR1
NCBI Protein Information
securin
UniProt Protein Name
Securin
UniProt Gene Name
PTTG1
UniProt Synonym Gene Names
EAP1; PTTG; TUTR1; Tumor-transforming protein 1; hPTTG
UniProt Entry Name
PTTG1_HUMAN
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Product Notes
The PTTG1 pttg1 (Catalog #AAA307712) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The PTTG1 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's PTTG1 can be used in a range of immunoassay formats including, but not limited to, IF (Immunofluorescence), WB (Western Blot). Researchers should empirically determine the suitability of the PTTG1 pttg1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PTTG1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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