Rabbit SCO1 Polyclonal Antibody | anti-SCO1 antibody

SCO1 Antibody

Cat. Num. AAA39681

• Gene Names: SCO1; SCOD1
• Reactivity: Human, Mouse, Rat
• Applications: Immunofluorescence, Immunohistochemistry, Western Blot, ELISA
• Purity: SCO1 Antibody is affinity chromatography purified via peptide column.
• Synonyms: SCO1, Antibody; SCO1 Antibody; SCO1; SCOD1; Protein SCO1 homolog; mitochondrial; SCO cytochrome oxidase deficient homolog 1 (yeast); anti-SCO1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: SCO1 Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 301

• Applicable Applications for anti-SCO1 antibody: IF (Immunofluorescence), IHC (Immunohistochemistry), WB (Western Blot), ELISA
• Conjugate: Unconjugated
• Immunogen: SCO1 antibody was raised against a 14 amino acid synthetic peptide from near the center of human SCO1.
• Buffer: SCO1 Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: SCO1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IF (Immunofluorescence)

(Immunofluorescence of SCO1 in Human Brain cells with SCO1 antibody at 20 μg/mL.)

IHC (Immunohiostchemistry)

(Immunohistochemistry of SCO1 in human brain tissue with SCO1 antibody at 2.5 μg/mL.)

WB (Western Blot)

(Western blot analysis of SCO1 in human brain tissue lysate with SCO1 antibody at (A) 0.5 and (B) 1 μg/mL.)

Related Product Information for anti-SCO1 antibody

SCO1 Antibody: Synthesis of cytochrome c oxidase 1 was initially identified in yeast as one of two cytochrome c oxidase (COX) assembly proteins that enable the assembly of cytochrome c holoenzyme, a complex that catalyzes the transfer of reducing equivalents from cytochrome c to molecular oxygen and pumps protons across the inner mitochondrial membrane. Like their yeast homologs, the function of both SCO1 and SCO2 are dependent on copper ion binding. Mutations in either gene can lead to cytochrome c oxidase respiratory chain defects, with a missense mutation in human SCO1 (P174L) associated with a fatal neonatal hepatopathy when the second allele is also non-functional, suggesting the pathology is due to loss of function. It has been suggested that this mutation alters the SCO1 affinity for the copper (I) ion, thus impairing the efficiency of copper transfer to the cytochrome c oxidase. At least two isoforms of SCO1 are known to exist and both are recognized by the SCO1 antibody. This SCO1 antibody has no cross-reactivity to SCO2.

NCBI and Uniprot Product Information

• NCBI GI #: 8134663
• NCBI GeneID: 6341
• UniProt Accession #: O75880; B2RDM0
• Molecular Weight: 33,814 Da
• NCBI Official Full Name: Protein SCO1 homolog, mitochondrial
• NCBI Official Synonym Full Names: SCO1 cytochrome c oxidase assembly protein
• NCBI Official Symbol: SCO1
• NCBI Official Synonym Symbols: SCOD1
• NCBI Protein Information: protein SCO1 homolog, mitochondrial; SCO cytochrome oxidase deficient homolog 1
• UniProt Protein Name: Protein SCO1 homolog, mitochondrial
• UniProt Gene Name: SCO1
• UniProt Synonym Gene Names: SCOD1
• UniProt Entry Name: SCO1_HUMAN