IHC (Immunohistochemistry)
(Immunohistochemistry of paraffin-embedded human colon cancer using AAA119176 at dilution 1:100)
Rabbit anti-Human Serine/threonine-protein kinase PLK2 Polyclonal Antibody | anti-PLK2 antibody
Rabbit anti-human Serine/threonine-protein kinase PLK2 polyclonal Antibody(PLK2)
Gene Names
PLK2; SNK; hSNK; hPlk2
Reactivity
Human
Applications
Immunohistochemistry, ELISA
Purity
Antigen Affinity Purified
Synonyms
Serine/threonine-protein kinase PLK2, Antibody; Rabbit anti-human Serine/threonine-protein kinase PLK2 polyclonal Antibody(PLK2); Polo-like kinase 2; PLK-2; hPlk2; Serine/threonine-protein kinase SNK; hSNK; Serum-inducible kinase; PLK2; SNK; anti-PLK2 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Antigen Affinity Purified
Sequence Length
671
Applicable Applications for anti-PLK2 antibody
IHC (Immunohistochemistry), ELISA
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Conjugate
Non-conjugated
Immunogen
Recombinant human Serine/threonine-protein kinase PLK2 protein(336-685aa)
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-9577 / sc-9575 / sc-25421
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
IHC (Immunohistochemistry)
(Immunohistochemistry of paraffin-embedded human colon cancer using AAA119176 at dilution 1:100)
IHC (Immunohistochemistry)
(Immunohistochemistry of paraffin-embedded human colon cancer using AAA119176 at dilution 1:100)
Related Product Information for anti-PLK2 antibody
Tumor suppressor serine/threonine-protein kinase involved in synaptic plasticity, centriole duplication and G1/S phase transition. Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates CENPJ, NPM1, RAPGEF2, RASGRF1, SNCA, SIPA1L1 and SYNGAP1. Plays a key role in synaptic plasticity and memory by regulating the Ras and Rap protein signaling: required for overactivity-dependent spine remodeling by phosphorylating the Ras activator RASGRF1 and the Rap inhibitor SIPA1L1 leading to their degradation by the proteasome. Conversely, phosphorylates the Rap activator RAPGEF2 and the Ras inhibitor SYNGAP1, promoting their activity. Also regulates synaptic plasticity independently of kinase activity, via its interaction with NSF that disrupts the interaction between NSF and the GRIA2 subunit of AMPARs, leading to a rapid rundown of AMPAR-mediated current that occludes long term depression. Required for procentriole formation and centriole duplication by phosphorylating CENPJ and NPM1, respectively. Its induction by p53/TP53 suggests that it may participate in the mitotic checkpoint following stress.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
78,237 Da
NCBI Official Full Name
serine/threonine-protein kinase PLK2 isoform 2
NCBI Official Synonym Full Names
polo like kinase 2
NCBI Official Symbol
PLK2
NCBI Official Synonym Symbols
SNK; hSNK; hPlk2
NCBI Protein Information
serine/threonine-protein kinase PLK2
UniProt Protein Name
Serine/threonine-protein kinase PLK2
UniProt Gene Name
PLK2
UniProt Synonym Gene Names
SNK; PLK-2; hPlk2; hSNK
UniProt Entry Name
PLK2_HUMAN
Similar Products
Product Notes
The PLK2 plk2 (Catalog #AAA119176) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit anti-human Serine/threonine-protein kinase PLK2 polyclonal Antibody(PLK2) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Serine/threonine-protein kinase PLK2 can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), ELISA. Researchers should empirically determine the suitability of the PLK2 plk2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Serine/threonine-protein kinase PLK2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.