IHC (Immunohiostchemistry)
(SPG7 Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of SPG7 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)
Rabbit anti-Human SPG7 Polyclonal Antibody | anti-SPG7 antibody
SPG7 Antibody (Center)
Gene Names
SPG7; CAR; PGN; CMAR; SPG5C
Reactivity
Human
Applications
Immunohistochemistry, ELISA, Western Blot
Purity
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Synonyms
SPG7, Antibody; SPG7 Antibody (Center); Paraplegin; 3424-; Spastic paraplegia 7 protein; SPG7; CAR; CMAR; PGN; anti-SPG7 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit Ig
Specificity
This SPG7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 115-141 amino acids from the Central region of human SPG7.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.5 (varies by lot)
Sequence Positions
115-141
Sequence Length
489
Applicable Applications for anti-SPG7 antibody
IHC (Immunohistochemistry), ELISA, WB (Western Blot)
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
IHC (Immunohiostchemistry)
(SPG7 Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of SPG7 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)
IHC (Immunohiostchemistry)
(SPG7 Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of SPG7 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)
WB (Western Blot)
(SPG7 Antibody (Center) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the SPG7 antibody detected the SPG7 protein (arrow).)
WB (Western Blot)
(SPG7 Antibody (Center) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the SPG7 antibody detected the SPG7 protein (arrow).)
Related Product Information for anti-SPG7 antibody
This gene encodes a nuclear-encoded mitochondrial
metalloprotease protein that is a member of the AAA (ATPases
associated with a variety of cellular activities) protein family.
Members of this protein family share an ATPase domain and have
roles in diverse cellular processes including membrane trafficking,
intracellular motility, organelle biogenesis, protein folding, and
proteolysis. Two transcript variants encoding distinct isoforms
have been identified for this gene. Mutations associated with this
gene cause autosomal recessive spastic paraplegia 7. [provided by
RefSeq].
metalloprotease protein that is a member of the AAA (ATPases
associated with a variety of cellular activities) protein family.
Members of this protein family share an ATPase domain and have
roles in diverse cellular processes including membrane trafficking,
intracellular motility, organelle biogenesis, protein folding, and
proteolysis. Two transcript variants encoding distinct isoforms
have been identified for this gene. Mutations associated with this
gene cause autosomal recessive spastic paraplegia 7. [provided by
RefSeq].
Product Categories/Family for anti-SPG7 antibody
References
Warnecke, T., et al. Mov. Disord. 25(4):413-420(2010)
Augustin, S., et al. Mol. Cell 35(5):574-585(2009)
Karlberg, T., et al. PLoS ONE 4 (10), E6975 (2009) :
Brugman, F., et al. Neurology 71(19):1500-1505(2008)
Tzoulis, C., et al. J. Neurol. 255(8):1142-1144(2008)
Augustin, S., et al. Mol. Cell 35(5):574-585(2009)
Karlberg, T., et al. PLoS ONE 4 (10), E6975 (2009) :
Brugman, F., et al. Neurology 71(19):1500-1505(2008)
Tzoulis, C., et al. J. Neurol. 255(8):1142-1144(2008)
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
88235
NCBI Official Full Name
paraplegin isoform 1
NCBI Official Synonym Full Names
spastic paraplegia 7 (pure and complicated autosomal recessive)
NCBI Official Symbol
SPG7
NCBI Official Synonym Symbols
CAR; PGN; CMAR; SPG5C
NCBI Protein Information
paraplegin
UniProt Protein Name
Paraplegin
UniProt Gene Name
SPG7
UniProt Synonym Gene Names
CAR; CMAR; PGN
UniProt Entry Name
SPG7_HUMAN
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Product Notes
The SPG7 spg7 (Catalog #AAA287831) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 115-141. The SPG7 Antibody (Center) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's SPG7 can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), ELISA, WB (Western Blot). Researchers should empirically determine the suitability of the SPG7 spg7 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SPG7, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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