Rabbit TANK Polyclonal Antibody | anti-TANK antibody

TANK Antibody

Cat. Num. AAA303848

• Gene Names: TANK; ITRAF; TRAF2; I-TRAF
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry, Western Blot, ELISA
• Purity: Affinity chromatography purified via peptide column
• Synonyms: TANK, Antibody; TANK Antibody; TRAF family member-associated NF-kappaB activator, I-TRAF; anti-TANK antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Purity/Purification: Affinity chromatography purified via peptide column
• Form/Format: Supplied in PBS containing 0.02% sodium azide.
• Sequence Length: 425

• Applicable Applications for anti-TANK antibody: IHC (Immunohistochemistry), WB (Western Blot), ELISA
• Immunogen Type: Peptide
• Immunogen Description: Raised against a 14 amino acid peptide from near the carboxy terminus of human TANK.
• Target Name: TANK
• Preparation and Storage: Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IHC (Immunohiostchemistry)

(Immunohistochemistry of TANK in rat spleen tissue with TANK antibody at 10 ug/mL.)

WB (Western Blot)

(Western blot analysis of TANK in Daudi cell lysate with TANK antibody at (A) 0.5, (B) 1 and (C) 2 ug/mL.)

Related Product Information for anti-TANK antibody

TANK was initially identified as a novel TRAF-interacting protein that regulated TRAF-mediated signal transduction. Specifically, ligand binding by surface receptors in the tumor necrosis factor (TNF) receptor and Toll/interleukin-1 (IL-1) receptor families lead to the formation of a TRAF/TANK complex that mediates the activation of the transcription factor NF-kB. This activation of NF-kB occurs through an association with the kinases IKKeta and TBK1. More recently, it was shown that these proteins can then form a complex with NEMO, a protein that regulates the activity of the IkB complex. This suggests that in addition to the possibility that TBK1 and IKKeta activate the IKKs, the association with the IKK complex may help these kinases modulate other functions, such as the transactivation potential of NF-kB proteins. At least two isoforms of TANK are known to exist.

Product Categories/Family for anti-TANK antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 19743569
• NCBI GeneID: 10010
• NCBI Accession #: NP_004171
• NCBI GenBank Nucleotide #: NM_004180.2
• Molecular Weight: 13,626 Da
• NCBI Official Full Name: TRAF family member-associated NF-kappa-B activator isoform a
• NCBI Official Synonym Full Names: TRAF family member-associated NFKB activator
• NCBI Official Symbol: TANK
• NCBI Official Synonym Symbols: ITRAF; TRAF2; I-TRAF
• NCBI Protein Information: TRAF family member-associated NF-kappa-B activator
• UniProt Protein Name: TRAF family member-associated NF-kappa-B activator
• UniProt Gene Name: TANK
• UniProt Synonym Gene Names: ITRAF; TRAF2; I-TRAF
• UniProt Entry Name: TANK_HUMAN