Rabbit TDP43 Polyclonal Antibody | anti-TARDBP antibody

TDP43 Antibody

Cat. Num. AAA39293

• Gene Names: TARDBP; ALS10; TDP-43
• Reactivity: Human, Mouse, Rat
• Applications: Immunofluorescence, Immunocytochemistry, Western Blot, ELISA
• Purity: TDP43 Antibody is affinity chromatography purified via peptide column.
• Synonyms: TDP43, Antibody; TDP43 Antibody; TDP43; ALS10; TDP-43; TAR DNA-binding protein 43; TAR DNA binding protein; anti-TARDBP antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: At least two isoforms are known to exist for this protein; this TDP43 antibody only recongizes the longer of the two isoforms.
• Purity/Purification: TDP43 Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 416

• Applicable Applications for anti-TARDBP antibody: IF (Immunofluorescence), ICC (Immunocytochemistry), WB (Western Blot), ELISA
• Conjugate: Unconjugated
• Immunogen: TDP43 antibody was raised against a 18 amino acid synthetic peptide from near the center of human TDP43.
• Buffer: TDP43 Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: TDP43 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IF (Immunofluorescence)

(Immunofluorescence of TDP43 in Hela cells with TDP43 antibody at 20 μg/mL.)

ICC (Immunocytochemistry)

(Immunocytochemistry of TDP43 in HeLa cells with TDP43 antibody at 5 μg/mL.)

WB (Western Blot)

(Western blot analysis of TDP43 in L1210 cell lysate with TDP43 antibody at (A) 0.5 and (B) 1 μg/mL.)

Related Product Information for anti-TARDBP antibody

TDP43 Antibody: TDP43 was initially identified as a novel cellular protein that bound to HIV-1 virus TAR DNA sequence motifs and acts a transcriptional repressor to the HIV-1 LTR. Later experiments revealed that TDP43 also regulates the splicing of exon 9 of the cystic fibrosis transmembrane conductance regular (CFTR), most likely through the association with the UG repeats at the 3'splice site. A hyperphosphorylated, ubiquitinated, and cleaved form of TDP43 known as pathologic TDP43 is the major disease protein in ubiquitin-positive, tau-, and alpha-synuclein-negative frontotemporal dementia (FLTD-U). TDP43 is not related to TRBP1, and RNA binding protein that binds HIV-1 TAR RNA sequences.

NCBI and Uniprot Product Information

• NCBI GI #: 130750552
• NCBI GeneID: 23435
• UniProt Accession #: Q13148; Q53H27; Q6FI92; Q96DJ0; A4GUK4; A4GUK5; A4GUK6; B2R629; B4DJ45; E2PU12
• Molecular Weight: 31,808 Da
• NCBI Official Full Name: TDP43
• NCBI Official Synonym Full Names: TAR DNA binding protein
• NCBI Official Symbol: TARDBP
• NCBI Official Synonym Symbols: ALS10; TDP-43
• NCBI Protein Information: TAR DNA-binding protein 43; TAR DNA-binding protein-43
• UniProt Protein Name: TAR DNA-binding protein 43
• UniProt Gene Name: TARDBP
• UniProt Synonym Gene Names: TDP43; TDP-43
• UniProt Entry Name: TADBP_HUMAN