IHC (Immunohiostchemistry)
(Immunohistochemistry of TERF2 in human kidney tissue with TERF2 antibody at 5 μg/mL.)
Rabbit anti-Human TERF2 Polyclonal Antibody | anti-TERF2 antibody
TERF2 Antibody
Gene Names
TERF2; TRF2; TRBF2
Reactivity
Human
Applications
Immunohistochemistry, Western Blot, ELISA
Purity
TERF2 antibody is affinity chromatography purified via peptide column.
Synonyms
TERF2, Antibody; TERF2 Antibody; TERF2; TRF2; TRBF2; Telomeric repeat-binding factor 2; TTAGGG repeat-binding factor 2; telomeric repeat binding factor 2; anti-TERF2 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Specificity
TERF2 antibody is human specific.
Purity/Purification
TERF2 antibody is affinity chromatography purified via peptide column.
Form/Format
Liquid
Concentration
1 mg/mL (varies by lot)
Sequence Length
542
Applicable Applications for anti-TERF2 antibody
IHC (Immunohistochemistry), WB (Western Blot), ELISA
Conjugate
Unconjugated
Immunogen
TERF2 antibody was raised against a 17 amino acid peptide near the amino terminus of human TERF2.
Buffer
TERF2 Antibody is supplied in PBS containing 0.02% sodium azide.
Preparation and Storage
TERF2 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year.
IHC (Immunohiostchemistry)
(Immunohistochemistry of TERF2 in human kidney tissue with TERF2 antibody at 5 μg/mL.)
IHC (Immunohiostchemistry)
(Immunohistochemistry of TERF2 in human kidney tissue with TERF2 antibody at 5 μg/mL.)
WB (Western Blot)
(Western blot analysis of TERF2 in 293 cell lysate with TERF2 antibody at 1 μg/ml.)
WB (Western Blot)
(Western blot analysis of TERF2 in 293 cell lysate with TERF2 antibody at 1 μg/ml.)
Related Product Information for anti-TERF2 antibody
The telomeric repeat binding factor family (TERF1 and TERF2) plays a key role in cellular immortalization and cellular senescence (1). TERF2, as a component of the telomere nucleoprotein complex, is present at telomeres in metaphase of the cell cycle (2). TERF2 is a second negative regulator of telomere length and binds as a dimer to TTAGGG repeats at ends of chromosomes (telomeres), where it blocks inappropriate activation of the ATM/p53 pathway (2,3). TERF1 negatively regulates telomere elongation, while TERF2 protects the chromosome ends by inhibiting end-to-end fusions. Down-regulation of TRF expression in tumor cells may contribute to cell immortalization and malignant progression (4,5).
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
Predicted: 60 kDa
Observed: 69 kDa
Observed: 69 kDa
NCBI Official Full Name
telomeric repeat-binding factor 2
NCBI Official Synonym Full Names
telomeric repeat binding factor 2
NCBI Official Symbol
TERF2
NCBI Official Synonym Symbols
TRF2; TRBF2
NCBI Protein Information
telomeric repeat-binding factor 2; telomeric DNA-binding protein; TTAGGG repeat-binding factor 2; telomeric repeat binding protein 2
UniProt Protein Name
Telomeric repeat-binding factor 2
UniProt Gene Name
TERF2
UniProt Synonym Gene Names
TRBF2; TRF2
UniProt Entry Name
TERF2_HUMAN
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Product Notes
The TERF2 terf2 (Catalog #AAA40606) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TERF2 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's TERF2 can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), WB (Western Blot), ELISA. Researchers should empirically determine the suitability of the TERF2 terf2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TERF2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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