Rabbit anti-Human TICAM1 Polyclonal Antibody | anti-TICAM1 antibody

TICAM1 Antibody

Cat. Num. AAA168841

• Gene Names: TICAM1; TRIF; IIAE6; MyD88-3; PRVTIRB; TICAM-1
• Reactivity: Human
• Applications: Immunohistochemistry, Western Blot
• Purity: Antigen affinity purification
• Synonyms: TICAM1, Antibody; TICAM1 Antibody; TRIF; PRVTIRB; TICAM-1; anti-TICAM1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen affinity purification
• Concentration: 1mg/mL (varies by lot)
• Sequence Length: 356

• Applicable Applications for anti-TICAM1 antibody: IHC (Immunohistochemistry), WB (Western Blot)
• Immunogen: Recombinant protein of human TICAM1
• Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-130621
• Preparation and Storage: Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.

IHC (Immunohistochemisry)

(Immunohistochemistry of paraffin-embedded Human spleen tissue using TRIF Polyclonal Antibody at dilution of 1:200.)

IHC (Immunohiostchemistry)

(Immunohistochemistry of paraffin-embedded Human lung cancer tissue using TRIF Polyclonal Antibody at dilution of 1:200.)

WB (Western Blot)

(Western Blot analysis of HepG2 cells using TRIF Polyclonal Antibody at dilution of 1:1000.)

Related Product Information for anti-TICAM1 antibody

Members of the Toll-like receptor (TLR) family, named for the closely related Toll receptor in Drosophila, play a pivotal role in innate immune responses (1-3). TLRs recognize conserved motifs found in various pathogens and mediate defense responses. Triggering of the TLR pathway leads to the activation of NF-kappaB and subsequent regulation of immune and inflammatory genes. The TLRs and members of the IL-1 receptor family share a conserved stretch of approximately 200 amino acids known as the TIR domain. Upon activation, TLRs associate with a number of cytoplasmic adaptor proteins containing TIR domains including MyD88 (myeloid differentiation factor), MAL/TIRAP (MyD88-adaptor-like/TIR-associated protein), TRIF (Toll-receptor-associated activator of interferon), and TRAM (Toll-receptor-associated molecule). This association leads to the recruitment and activation of IRAK1 and IRAK4, which form a complex with TRAF6 to activate TAK1 and IKK. Activation of IKK leads to the degradation of IkappaB that normally maintains NF-kappaB inactivity by sequestering it in the cytoplasm. TRIF (also termed TICAM-1) is a TIR-domain adaptor protein described to activate NF-kappaB, IRF3 and trigger IFN-beta production (4, 5). Studies using dominant negative forms of TRIF and siRNA targeting TRIF show that TRIF functions downstream of both TLR3 and TLR4 in response to dsRNA and LPS respectively (4-6). TRIF recruits TRAF6-TAK1-TAB2 to the receptor complex which leads to NF-kappaB activation (7). In addition, TRIF can trigger signaling of that lead to the induction of apoptosis (8).

NCBI and Uniprot Product Information

• NCBI GI #: 33874778
• NCBI GeneID: 148022
• Molecular Weight: 76,422 Da
• NCBI Official Full Name: TICAM1 protein, partial
• NCBI Official Synonym Full Names: toll-like receptor adaptor molecule 1
• NCBI Official Symbol: TICAM1
• NCBI Official Synonym Symbols: TRIF; IIAE6; MyD88-3; PRVTIRB; TICAM-1
• NCBI Protein Information: TIR domain-containing adapter molecule 1; TIR domain containing adaptor inducing interferon-beta; TIR domain-containing adapter protein inducing IFN-beta; proline-rich, vinculin and TIR domain-containing protein B; putative NF-kappa-B-activating protein 502H; toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta
• UniProt Protein Name: TIR domain-containing adapter molecule 1
• UniProt Gene Name: TICAM1
• UniProt Synonym Gene Names: PRVTIRB; TRIF; TICAM-1; MyD88-3; TIR domain-containing adapter protein inducing IFN-beta
• UniProt Entry Name: TCAM1_HUMAN