anti-Human TRAF2 Polyclonal Antibody | anti-TRAF2 antibody

Anti-TRAF2 Antibody

Cat. Num. AAA46553

• Gene Names: TRAF2; TRAP; TRAP3; MGC:45012
• Reactivity: Human
• Applications: Immunohistochemistry, Western Blot
• Purity: Immunogen Affinity Purified
• Synonyms: TRAF2, Antibody; Anti-TRAF2 Antibody; TNF receptor-associated factor 2; E3 ubiquitin-protein ligase TRAF2; MGC:45012; OTTHUMP00000022625; OTTHUMP00000064745; TNF receptor associated factor 2; TNF receptor-associated protein; TRAF 2; TRAF2; TRAF2_HUMAN; TRAP 3; TRAP; TRAP3; Tumor necrosis factor type 2 receptor associated protein 3; Tumor necrosis factor type 2 receptor-associated protein 3 antibody; anti-TRAF2 antibody

• Reactivity: Human
• Clonality: Polyclonal
• Purity/Purification: Immunogen Affinity Purified
• Form/Format: Lyophilized. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
• Sequence Length: 501

• Applicable Applications for anti-TRAF2 antibody: IHC (Immunohistochemistry), WB (Western Blot)
• Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human TRAF2 (308-339aa RLDQDKIEALSSKVQQLERSIGLKDLAMADLE), different from the related mouse sequence by one amino acid.
• Ig Type: Rabbit IgG
• Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
• Preparation and Storage: At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquoted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

IHC (Immunohiostchemistry)

(Anti- TRAF2 Picoband antibody, AAA46553, IHC(P)IHC(P): Human Tonsil Tissue)

WB (Western Blot)

(Anti- TRAF2 Picoband antibody, AAA46553, Western blottingAll lanes: Anti TRAF2 (AAA46553) at 0.5ug/mlLane 1: HELA Whole Cell Lysate at 40ugLane 2: JURKAT Whole Cell Lysate at 40ugPredicted bind size: 56KDObserved bind size: 56KD)

Related Product Information for anti-TRAF2 antibody

Description: Rabbit IgG polyclonal antibody for TNF receptor-associated factor 2(TRAF2) detection. Tested with WB, IHC-P in Human.

Background: TRAF2 (TNF Receptor-Associated Factor 2), also called TRAP, is a protein that in humans is encoded by the TRAF2 gene. The protein encoded by this gene is a member of the TNF receptor (TNFR) associated factor (TRAF) protein family. TRAF2 is a common signal transducer for TNFR2 and CD40 that mediates activation of NF-kappa-B. Rothe et al. (1996) identified ITRAF, which binds to TRAF1, TRAF2, and TRAF3, and that when overexpressed inhibits TRAF2-mediated NF-kappa-B activation. They proposed that ITRAF is an inhibitor of TRAF function that regulates TRAF protein activity by sequestering TRAFs in a latent state in the cytoplasm. Kanamori et al. (2002) found that mouse Traf2 interacted directly with T2bp, and they presented evidence that T2BP is involved in TNF-mediated signaling by its interaction with TRAF2.

References

1. Aizawa, S., Nakano, H., Ishida, T., Horie, R., Nagai, M., Ito, K., Yagita, H., Okumura, K., Inoue, J., Watanabe, T. Tumor necrosis factor receptor-associated factor (TRAF) 5 and TRAF2 are involved in CD30-mediated NF-kappa-B activation. J. Biol. Chem. 272: 2042-2045, 1997. 2. Kanamori, M., Suzuki, H., Saito, R., Muramatsu, M., Hayashizaki, Y. T2BP, a novel TRAF2 binding protein, can activate NF-kappa-B and AP-1 without TNF stimulation. Biochem. Biophys. Res. Commun. 290: 1108-1113, 2002. 3. Rothe, M., Xiong, J., Shu, H.-B., Williamson, K., Goddard, A., Goeddel, D. V. I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction. Proc. Nat. Acad. Sci. 93: 8241-8246, 1996.

NCBI and Uniprot Product Information

• NCBI GI #: 22027612
• NCBI GeneID: 7186
• NCBI Accession #: NP_066961.2
• NCBI GenBank Nucleotide #: NM_021138.3
• UniProt Accession #: Q12933; Q7Z337; Q96NT2; A8K107; B4DPJ7
• Molecular Weight: 53,055 Da
• NCBI Official Full Name: TNF receptor-associated factor 2
• NCBI Official Synonym Full Names: TNF receptor associated factor 2
• NCBI Official Symbol: TRAF2
• NCBI Official Synonym Symbols: TRAP; TRAP3; MGC:45012
• NCBI Protein Information: TNF receptor-associated factor 2
• UniProt Protein Name: TNF receptor-associated factor 2
• UniProt Gene Name: TRAF2
• UniProt Synonym Gene Names: TRAP3
• UniProt Entry Name: TRAF2_HUMAN