WB (Western Blot)
(Anti-TSHR Antibody (Center) at 1:1000 dilution + mouse liver lysatesLysates/proteins at 20 ug per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilutionPredicted band size : 87 kDaBlocking/Dilution buffer: 5% NFDM/TBST.)
Rabbit anti-Mouse TSHR Polyclonal Antibody | anti-TSHR antibody
TSHR Antibody (Center)
Gene Names
TSHR; LGR3; CHNG1; hTSHR-I
Reactivity
Mouse
Applications
ELISA, Western Blot
Purity
Purified Rabbit Polyclonal Antibody (Pab)
Synonyms
TSHR, Antibody; TSHR Antibody (Center); Thyrotropin receptor; Thyroid-stimulating hormone receptor; TSH-R; TSHR; LGR3; anti-TSHR antibody
Host
Rabbit
Reactivity
Mouse
Clonality
Polyclonal
Isotype
Rabbit Ig
Specificity
This TSHR antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 217-252 amino acids from the Central region of human TSHR.
Purity/Purification
Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Sequence Length
274
Applicable Applications for anti-TSHR antibody
ELISA, WB (Western Blot)
Function
Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin (PubMed:11847099,
PubMed:12045258). Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin (PubMed:12045258). The activity of this receptor is mediated by
G proteins which activate adenylate cyclase (PubMed:11847099). Plays a central role in controlling
thyroid cell metabolism (By similarity).Function
Cellular location
Cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein.
Tissue location
Expressed in thyroide cells (at protein level) (PubMed:11847099). Expressed in the thyroid (PubMed:2610690.
Preparation and Storage
Maintain refrigerated at 2-8 degree for up to 2 weeks. For long term storage store at -20 degree in small aliquots to prevent freeze-thaw cycles.
aliquots to prevent freeze-thaw cycles.
WB (Western Blot)
(Anti-TSHR Antibody (Center) at 1:1000 dilution + mouse liver lysatesLysates/proteins at 20 ug per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilutionPredicted band size : 87 kDaBlocking/Dilution buffer: 5% NFDM/TBST.)
WB (Western Blot)
(Anti-TSHR Antibody (Center) at 1:1000 dilution + mouse liver lysatesLysates/proteins at 20 ug per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilutionPredicted band size : 87 kDaBlocking/Dilution buffer: 5% NFDM/TBST.)
Related Product Information for anti-TSHR antibody
Receptor for thyrothropin. Plays a central role in controlling thyroid cell metabolism. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Also acts as a receptor for thyrostimulin (GPA2+GPB5).
References
Nagayama Y.,et al.Biochem. Biophys. Res. Commun. 165:1184-1190(1989).
Libert F.,et al.Biochem. Biophys. Res. Commun. 165:1250-1255(1989).
Misrahi M.,et al.Biochem. Biophys. Res. Commun. 166:394-403(1990).
Frazier A.L.,et al.Mol. Endocrinol. 4:1264-1276(1990).
Graves P.N.,et al.Biochem. Biophys. Res. Commun. 187:1135-1143(1992).
Libert F.,et al.Biochem. Biophys. Res. Commun. 165:1250-1255(1989).
Misrahi M.,et al.Biochem. Biophys. Res. Commun. 166:394-403(1990).
Frazier A.L.,et al.Mol. Endocrinol. 4:1264-1276(1990).
Graves P.N.,et al.Biochem. Biophys. Res. Commun. 187:1135-1143(1992).
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
Calculated MW 86844
NCBI Official Full Name
thyrotropin receptor isoform 1
NCBI Official Synonym Full Names
thyroid stimulating hormone receptor
NCBI Official Symbol
TSHR
NCBI Official Synonym Symbols
LGR3; CHNG1; hTSHR-I
NCBI Protein Information
thyrotropin receptor
UniProt Protein Name
Thyrotropin receptor
UniProt Gene Name
TSHR
UniProt Synonym Gene Names
LGR3; TSH-R
UniProt Entry Name
TSHR_HUMAN
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Product Notes
The TSHR tshr (Catalog #AAA290046) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TSHR Antibody (Center) reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's TSHR can be used in a range of immunoassay formats including, but not limited to, ELISA, WB (Western Blot). Researchers should empirically determine the suitability of the TSHR tshr for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TSHR, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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