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IHC (Immunohistochemistry)
(UCHL1/PGP9.5 Antibody-Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE))
Rabbit anti-Human UCHL1/PGP9.5 Polyclonal Antibody | anti-UCHL1 antibody
UCHL1/PGP9.5 Rabbit anti-Human Polyclonal Antibody
Gene Names
UCHL1; PARK5; PGP95; PGP9.5; Uch-L1; PGP 9.5
Reactivity
Human
Applications
Immunohistochemistry
Purity
Immunoaffinity purified
Synonyms
UCHL1/PGP9.5, Antibody; UCHL1/PGP9.5 Rabbit anti-Human Polyclonal Antibody; PathPlus UCHL1/PGP9.5 Antibody; UCHL1; Ubiquitin C-terminal hydrolase; PARK5; PGP9.5; PGP95; Ubiquitin thioesterase L1; Neuron cytoplasmic protein 9.5; PGP 9.5; Uch-L1; Ubiquitin carboxyl-terminal esterase L1; HEL-117; NDGOA; HEL-S-53; SPG79; anti-UCHL1 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Purity/Purification
Immunoaffinity purified
Form/Format
PBS, 0.1% Sodium Azide
Concentration
1mg/ml (varies by lot)
Applicable Applications for anti-UCHL1 antibody
IHC (Immunohistochemistry)
Target
Human UCHL1/PGP9.5
Immunogen
LP-12500, synthetic peptide
Conjugation
Unconjugated
Family
Protease
Subfamily
Cysteine C12
Preparation and Storage
Aliquot and store undiluted at -20 degree C or below for up to 1 year. Can be stored undiluted at 4 degree C for up to 1 month. Avoid freeze-thaw cycles.
IHC (Immunohistochemistry)
(UCHL1/PGP9.5 Antibody-Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohistochemistry)
(UCHL1/PGP9.5 Antibody-Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohistochemisry)
(UCHL1/PGP9.5 Antibody-Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohistochemisry)
(UCHL1/PGP9.5 Antibody-Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohiostchemistry)
(UCHL1/PGP9.5 Antibody-Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohiostchemistry)
(UCHL1/PGP9.5 Antibody-Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohistochemistry)
(UCHL1/PGP9.5 Antibody-Human Pancreas: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohistochemistry)
(UCHL1/PGP9.5 Antibody-Human Pancreas: Formalin-Fixed, Paraffin-Embedded (FFPE))
Related Product Information for anti-UCHL1 antibody
PGP9.5 antibody is an unconjugated rabbit polyclonal antibody to PGP9.5 (UCHL1) from human. Validated for IHC.
UCHL1 is a deubiquitinating enzyme found in neurons and neuroendocrine cells. UCHL1 functions to promote neuronal differentiation and regulates autophagy. UCHL1 is also considered an oncogene; mice engineered to overexpress UCHL1 demonstrate a propensity for lymphogenesis and malignancy, and abnormal expression of UCHL1 is seen in some lung and endometrial cancers. It has also been implicated in a number of neurodegenerative disorders including Parkinson's and Alzheimer's disease. In immunohistochemistry of normal tissue, UCHL1 is positive in neurons in the central nervous system. It is also present in a number of other tissues and cell types including distal renal tubules, islets of Langerhans, spermatogonia in testis, Leydig cells, oocytes and melanocytes.
UCHL1 is a deubiquitinating enzyme found in neurons and neuroendocrine cells. UCHL1 functions to promote neuronal differentiation and regulates autophagy. UCHL1 is also considered an oncogene; mice engineered to overexpress UCHL1 demonstrate a propensity for lymphogenesis and malignancy, and abnormal expression of UCHL1 is seen in some lung and endometrial cancers. It has also been implicated in a number of neurodegenerative disorders including Parkinson's and Alzheimer's disease. In immunohistochemistry of normal tissue, UCHL1 is positive in neurons in the central nervous system. It is also present in a number of other tissues and cell types including distal renal tubules, islets of Langerhans, spermatogonia in testis, Leydig cells, oocytes and melanocytes.
References
Chemistry & Biology. 10 (9): 837 -46. doi:10.1016/j.chembiol.2003.08.010. PMID: 14522054; Leukemia. 2010 Sep;24(9):1641-55, PMID: 20574456; J Exp Clin Cancer Res. 2018 Oct 25;37(1):258, PMID: 30359286; Int J Gynecol Cancer. 2018 May;28(4):675-683, PMID: 29489474
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
24,824 Da
NCBI Official Full Name
ubiquitin carboxyl-terminal hydrolase isozyme L1
NCBI Official Synonym Full Names
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
NCBI Official Symbol
UCHL1
NCBI Official Synonym Symbols
PARK5; PGP95; PGP9.5; Uch-L1; PGP 9.5
NCBI Protein Information
ubiquitin carboxyl-terminal hydrolase isozyme L1; ubiquitin thioesterase L1; neuron cytoplasmic protein 9.5; ubiquitin C-terminal hydrolase
UniProt Protein Name
Ubiquitin carboxyl-terminal hydrolase isozyme L1
UniProt Gene Name
UCHL1
UniProt Synonym Gene Names
UCH-L1; PGP9.5
UniProt Entry Name
UCHL1_HUMAN
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Product Notes
The UCHL1 uchl1 (Catalog #AAA163157) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The UCHL1/PGP9.5 Rabbit anti-Human Polyclonal Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's UCHL1/PGP9.5 can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry). Researchers should empirically determine the suitability of the UCHL1 uchl1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "UCHL1/PGP9.5, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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