IHC (Immunohiostchemistry)
(Immunohistochemical staining of human spleen tissue using XAF-1 antibody at 2 ug/mL.)
Rabbit anti-Human, Mouse XAF-1 Polyclonal Antibody | anti-XAF-1 antibody
XAF-1 Antibody
Gene Names
XAF1; BIRC4BP; XIAPAF1; HSXIAPAF1
Reactivity
Human, Mouse
Applications
Immunohistochemistry, Western Blot, ELISA
Purity
Affinity chromatography purified via peptide column
Synonyms
XAF-1, Antibody; XAF-1 Antibody; anti-XAF-1 antibody
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Purity/Purification
Affinity chromatography purified via peptide column
Form/Format
Supplied in PBS containing 0.02% sodium azide.
Sequence Length
317
Applicable Applications for anti-XAF-1 antibody
IHC (Immunohistochemistry), WB (Western Blot), ELISA
Immunogen Type
Peptide
Immunogen Description
Raised against a synthetic peptide corresponding to amino acids at the C-terminus of human XAF-1.
Target Name
XAF-1
Preparation and Storage
Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
IHC (Immunohiostchemistry)
(Immunohistochemical staining of human spleen tissue using XAF-1 antibody at 2 ug/mL.)
IHC (Immunohiostchemistry)
(Immunohistochemical staining of human spleen tissue using XAF-1 antibody at 2 ug/mL.)
WB (Western Blot)
(Western blot analysis of XAF-1 in human spleen lysate with XAF-1 antibody at 0.5 (lane A), 1 (lane B), and 2 (lane C) ug/mL, respectively.)
WB (Western Blot)
(Western blot analysis of XAF-1 in human spleen lysate with XAF-1 antibody at 0.5 (lane A), 1 (lane B), and 2 (lane C) ug/mL, respectively.)
Related Product Information for anti-XAF-1 antibody
XAF-1 binds to XIAP, an inhibitor of caspases-3, -7, and -9, and triggers its relocation from the cytosol to the nucleus. Overexpression of XAF-1 results in the neutralization of XIAP's ability to inhibit cell death. XAF-1 is normally expressed in all adult and fetal tissues but was found to be present in very low levels in a variety of cancer cell lines. In contrast, XIAP levels have been shown to be high in a majority of cell lines. Low XAF-1 and high basal expression of XIAP may therefore play a critical role in maintaining survival of cancer cell lines. Both IFN-alpha2 and IFN-beta can induce XAF-1 mRNA in all cells examined but induction of XAF-1 protein (as observed by immunoblot analysis) was seen only in cell lines sensitive to the apoptotic effects of IFNs.
Product Categories/Family for anti-XAF-1 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
34,543 Da
NCBI Official Full Name
XIAP associated factor-1 (ZAP-1)
NCBI Official Synonym Full Names
XIAP associated factor 1
NCBI Official Symbol
XAF1
NCBI Official Synonym Symbols
BIRC4BP; XIAPAF1; HSXIAPAF1
NCBI Protein Information
XIAP-associated factor 1
UniProt Protein Name
XIAP-associated factor 1
UniProt Gene Name
XAF1
UniProt Synonym Gene Names
BIRC4BP; XIAPAF1
UniProt Entry Name
XAF1_HUMAN
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Product Notes
The XAF-1 xaf1 (Catalog #AAA304723) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The XAF-1 Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's XAF-1 can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), WB (Western Blot), ELISA. Researchers should empirically determine the suitability of the XAF-1 xaf1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "XAF-1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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