RAB7 Blocking Peptide | RAB7A blocking peptide

RAB7 Antibody (C-term) Blocking Peptide

Cat. Num. AAA290816

• Gene Names: RAB7A; RAB7; PRO2706
• Synonyms: RAB7; N/A; RAB7 Antibody (C-term) Blocking Peptide; Ras-related protein Rab-7a, RAB7A, RAB7; RAB7A blocking peptide

• Clone Number: 90504025
• Specificity: The synthetic peptide sequence used to generate the antibody (please inquire) was selected from the C-term region of human RAB7. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 207

• Clone Names: 90504025
• Peptide ID: 90504025
• Cellular Location: Cytoplasmic vesicle, phagosome membrane;Peripheral membrane protein; Cytoplasmicside. Late endosome membrane; Peripheralmembrane protein; Cytoplasmic side.Lysosome membrane; Peripheral membraneprotein; Cytoplasmic side. Melanosomemembrane; Peripheral membrane protein;Cytoplasmic side. Cytoplasmic vesicle,autophagosome membrane; Peripheralmembrane protein; Cytoplasmic side. Lipiddroplet {ECO:0000250|UniProtKB:P51150}.Endosome membrane. Note=Colocalizes withOSBPL1A at the late endosome(PubMed:16176980). Found in the ruffledborder (a late endosomal-like compartment inthe plasma membrane) of bone-resorbingosteoclasts. Recruited to phagosomescontaining S.aureus or Mycobacterium(PubMed:21255211). Lipid droplet localizationis increased upon ADRB2 stimulation (By similarity) {ECO:0000250 | UniProtKB:P51150, ECO:0000269 | PubMed:16176980, ECO:0000269 |PubMed:21255211}
• Tissue Location: Widely expressed; high expression found in skeletal muscle.
• Preparation and Storage: Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.

Related Product Information for RAB7A blocking peptide

Background: RAB family members are small, RAS-related GTP-binding proteins that are important regulators of vesicular transport. Each RAB protein targets multiple proteins that act in exocytic / endocytic pathways. RAB7 is a RAB family member that regulates vesicle traffic in the late endosomes and also from late endosomes to lysosomes. This protein is also involved in the cellular vacuolation of the VacA cytotoxin of Helicobacter pylori.

Function: Key regulator in endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Plays a central role, not RAB7 Antibody (C-term) Blocking Peptide - Background RAB family members are small, RAS-related GTP-binding proteins that are important regulators of vesicular transport. Each RAB protein targets multiple proteins that act in exocytic / endocytic pathways. RAB7 is a RAB family member that regulates vesicle traffic in the late endosomes and also from late endosomes to lysosomes. This protein is also involved in the cellular vacuolation of the VacA cytotoxin of Helicobacter pylori. RAB7 Antibody (C-term) Blocking Peptide - References Davies,J.P., et.al., Genomics 41 (1), 131-134 (1997)Vitelli,R., et.al., Biochem. Biophys. Res. Commun. 229 (3), 887-890 (1996) only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient- transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in regulation of some specialized endosomal membrane trafficking, such as maturation of melanosomes, pathogen-induced phagosomes (or vacuoles) and autophagosomes. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes. Plays important roles in microbial pathogen infection and survival, as well as in participating in the life cycle of viruses. Microbial pathogens possess survival strategies governed by RAB7A, sometimes by employing RAB7A function (e.g. Salmonella) and sometimes by excluding RAB7A function (e.g. Mycobacterium). In concert with RAC1, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. Controls the endosomal trafficking and neurite outgrowth signaling of NTRK1/TRKA (PubMed:11179213, PubMed:12944476,PubMed:14617358, PubMed:20028791,PubMed:21255211). Regulatesthe endocytic trafficking of the EGF- EGFRcomplex by regulating its lysosomaldegradation. Involved in the ADRB2-stimulated lipolysis through lipophagy, a cytosolic lipase-independent autophagic pathway (By similarity). Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413).

NCBI and Uniprot Product Information

• NCBI GI #: 1709999
• NCBI GeneID: 7879
• UniProt Accession #: P51149; Q9NWJ0; Q9UPB0; A8K3V6
• NCBI Official Full Name: Ras-related protein Rab-7a
• NCBI Official Synonym Full Names: RAB7A, member RAS oncogene family
• NCBI Official Symbol: RAB7A
• NCBI Official Synonym Symbols: RAB7; PRO2706
• NCBI Protein Information: ras-related protein Rab-7a
• UniProt Protein Name: Ras-related protein Rab-7a
• UniProt Gene Name: RAB7A
• UniProt Synonym Gene Names: RAB7
• UniProt Entry Name: RAB7A_HUMAN