Rabbit anti-Human CD71/Transferrin Receptor (TFRC) Antibody | anti-TFRC antibody

CD71/Transferrin Receptor (TFRC) (Extracellular Domain)

Cat. Num. AAA215217

• Gene Names: TFRC; T9; TR; TFR; p90; CD71; TFR1; TRFR; IMD46
• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Purified Ab with BSA and Azide at 200ug/ml OR Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
• Synonyms: CD71/Transferrin Receptor (TFRC); N/A; CD71/Transferrin Receptor (TFRC) (Extracellular Domain); Mtvr-1; p90; TFR1; TFRC transferrin receptor (p90 CD71); TRFR; anti-TFRC antibody

• Host: Rabbit
• Reactivity: Human
• Isotype: IgG
• Clone Number: TFRC/2898R
• Specificity: It recognizes a ~90-95kDa protein which is identified as cell surface transferrin receptor (CD71), a disulfide-bonded homodimeric glycoprotein of 180-190kDa. This MAb is highly specific to CD71 and shows no cross-reaction with other related proteins. Ligand for transferrin receptor is the serum iron transport protein, transferrin. This receptor is broadly distributed in carcinomas, sarcomas, leukemias, and lymphomas. CD71/Transferrin receptor has been reported to be associated with cell proliferation in both normal and neoplastic tissues and useful in predicting clinical behavior or response to therapy in a number of malignancies including breast cancer.
• Purity/Purification: Purified Ab with BSA and Azide at 200ug/ml OR Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
• Form/Format: 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
• Sequence Length: 760

• Applicable Applications for anti-TFRC antibody: IHC (Immunohistochemistry)
• Positive Control: Jurkat, HeLa, MCF-7 or K562 cells. Human placenta or Bone Marrow.
• Immunogen: Recombinant human extracellular TFRC protein fragment (aa94-212) (exact sequence is proprietary)
• Cellular Localization: Cell Surface
• Hu-chromosome Location: 3q29
• Antibody Type: Recombinant Rabbit Monoclonal Antibody
• Preparation and Storage: Antibody with azide: store at 2 to 8 degree C.; Antibody without azide: store at -20 to -80 degree C.; Antibody is stable for 24 months. Non-hazardous. No MSDS required.

SDS-PAGE

(SDS-PAGE Analysis Purified CD71 Rabbit Recombinant Monoclonal Antibody (TFRC/2898R). Confirmation of Purity and Integrity of Antibody.)

IHC (Immunohistochemistry)

(Formalin-fixed, paraffin-embedded Human Bone Marrow stained with CD71 Rabbit Recombinant Monoclonal Antibody (TFRC/2898R).)

References

1. K. Moolenaar et al. Cancer research 50,1102-1106, 1990. 2. Oudermans et al. Cancer, 1986; 58:125

NCBI and Uniprot Product Information

• NCBI GI #: 189458819
• NCBI GeneID: 7037
• NCBI Accession #: NP_001121620.1
• NCBI GenBank Nucleotide #: NP_001121620.1
• UniProt Accession #: P02786
• Molecular Weight: 85-95kDa (monomer); 190kDa (dimer)
• NCBI Official Full Name: transferrin receptor protein 1 isoform 1
• NCBI Official Synonym Full Names: transferrin receptor
• NCBI Official Symbol: TFRC
• NCBI Official Synonym Symbols: T9; TR; TFR; p90; CD71; TFR1; TRFR; IMD46
• NCBI Protein Information: transferrin receptor protein 1
• UniProt Protein Name: Transferrin receptor protein 1
• UniProt Gene Name: TFRC
• UniProt Synonym Gene Names: TR; TfR; TfR1; Trfr; sTfR
• UniProt Entry Name: TFR1_HUMAN